if (!requireNamespace("tidyverse", quietly = TRUE))
install.packages('tidyverse')
if (!requireNamespace("Seurat", quietly = TRUE))
install.packages('Seurat')
if (!requireNamespace("colorBlindness", quietly = TRUE))
install.packages('colorBlindness')
if (!requireNamespace("RColorBrewer", quietly = TRUE))
install.packages('RColorBrewer')
if (!requireNamespace("DoubletFinder", quietly = TRUE))
remotes::install_github('chris-mcginnis-ucsf/DoubletFinder')5 - Quality Control
Quality Control
Introduction
This notebook reviews the quality control steps recommended at the beginning and at each subsequent annotation phase in analyzing scRNA-seq. In order to denoise a sparse cell by gene matrix, we take out non-informative cell data to create a better representation of an experiment. In this notebook, we will look at UMI and gene counts, filter out cells with high mitochondrial levels, investigate potential doublets (using DoubletFinder), and compare the cell by gene distribution before and after filtering.
Key Takeaways
QC is the process of filtering out “bad” data which makes it a subjective process where being conservative about what to keep and well-informed about your data is the best practice.
QC metrics include UMI and gene counts, mitochondrial gene expression, and doublet detection.
When in doubt, keep it. Once you remove something, you’ll never get it back.
Why are mitochondrial genes highly expressed and found in many datasets?
There is a disproportionate number of mitochondrial-high cells because cells upregulate mitochondrial genes during stress (such as during library prep) and near death.
From Orchestrating single-cell analysis with Bioconductor:
“High proportions (of mitochondria) are indicative of poor-quality cells (Islam et al. 2014; Ilicic et al. 2016), presumably because of loss of cytoplasmic RNA from perforated cells. The reasoning is that, in the presence of modest damage, the holes in the cell membrane permit efflux of individual transcript molecules but are too small to allow mitochondria to escape, leading to a relative enrichment of mitochondrial transcripts.”
Glossary
Doublet:
A doublet is a technical event when two or more cells end up within the same droplet. These cause confusion in the gene expression distribution especially when cells of two different cell types (different expected gene expression profiles) are in the same droplet.
Heterotypic doublets vs Homotypic doublets
A heterotypic doublet is a doublet with cells from distinct gene expression profiles that are likely different cell types.
A homotypic doublet is a doublet with cells with similar gene expression profiles that are not necessarily different cell types but are suspicious because they express around double the amount that other cells do.
Resources
Current best practices in single-cell RNA-seq analysis: a tutorial
Bioconductor: Orchestrating single-cell analysis with Bioconductor
-
A software that can access most popular demulitplexing and doublet detection tools. I used it as a review and consolidation of resources.
Loading Libraries and Data
suppressPackageStartupMessages({
library(Seurat)
library(tidyverse)
library(RColorBrewer)
library(colorBlindness)
library(DoubletFinder)
})
set.seed(687)# Load Seurat object
se <- readRDS('../data/Covid_Flu_Seurat_Object.rds')
seAn object of class Seurat
33234 features across 59572 samples within 1 assay
Active assay: RNA (33234 features, 0 variable features)
1 layer present: counts# Set color palette
pal <- paletteMartin
names(pal) <- sort(unique(se$Celltype))Filter out the overexpressed genes
Let’s look at the number of counts per barcode, the number of genes per barcode, and the percentage of mitochondrial genes per barcode. These distributions will help us determine the quality of the data by allowing us to see any outliers. These outliers could be dying cells with high mitochondrial counts or doublets with high gene counts.
In public datasets, use colnames() to find the processing and metadata already analyzed.
# Correct calculation of the number of metadata variables
vars <- length(colnames(se@meta.data))
# Use paste0 for concatenation without spaces
print(paste0("There are ", vars, " metadata variables in the seurat object."))[1] "There are 49 metadata variables in the seurat object."# Sample the first 10 metadata variables
colnames(se@meta.data)[1:10] [1] "orig.ident" "nCount_RNA" "nFeature_RNA" "Sample ID" "Disease group" "Comorbidity" "Hospital day" "WBC per microL" "Neutrophil per microL (%)" "Lymphocyte per microL (%)"1 - Number of UMIs
nCount_RNA is the number of UMIs per cell. This is a measure of the total number of transcripts detected in a cell and is a good way to visualize the library size. Cells with low nCount_RNA values may be dying cells or biologically relevant cell types with low mRNA content such as neutrophils. Cells with high nCount_RNA values may be doublets or very large cells like macrophages. Note the figure below plots UMIs on a log10 scale.
ggplot(se@meta.data, aes(x = nCount_RNA)) +
geom_density(color = "#6abcb6", fill = "#6abcb6", alpha = 0.7) +
scale_x_continuous(
transform = "log10",
labels = scales::unit_format(unit = "K", scale = 1e-3)) +
theme_classic() +
scale_color_manual(values = pal)
Plotting the UMIs by cell type shows that if we were to make a hard cut off at 500 UMIs, we would lose a large portion of platelets.
ggplot(se@meta.data, aes(x = nCount_RNA, fill = Celltype)) +
geom_density(alpha = 0.7) +
# Hard cutoff at 500 elicits loss in important cells
geom_vline(xintercept = 500, linetype = "dashed", color = "red") +
scale_x_continuous(
transform = "log10",
labels = scales::unit_format(unit = "K", scale = 1e-3)) +
theme_classic() +
scale_color_manual(values = pal)
2 - Number of genes
nFeature_RNA is the number of genes detected in a cell. Similarly, we want to look for cells with significantly low or high feature count. The feature count distribution gives us an idea of library complexity while UMI counts looks at library size. Note that the figure below plots genes (features) on a log10 scale.
ggplot(se@meta.data, aes(x = nFeature_RNA)) +
geom_density(color = "#6abcb6", fill = "#6abcb6", alpha = 0.7) +
scale_x_continuous(
transform = "log10",
labels = scales::unit_format(unit = "K", scale = 1e-3)) +
theme_classic() +
scale_color_manual(values = pal)
A plot showing incredibly high number of genes per cell is indicative of doublets or large cells. Cells on the left side of the distribution with low gene counts could be low quality cells or just RBCs or platelets.
3 - Percentage of mitochondrial genes
Notice the object already has Percent of mitochondrial genes calculated. We are going to calculate them again to show the process.
Seurat’s PercentageFeatureSet function calculates the percentage of a feature set in each cell. This function is useful for calculating the percentage of mitochondrial genes, ribosomal genes, or any other gene set of interest using regular expression (string matching) to filter these out by gene name.
# Calculate the percentage of mitochondrial genes
se <- PercentageFeatureSet(se, pattern = "^MT-", col.name = "perc.mt")
# Calculate the percentage of ribosomal genes
se <- PercentageFeatureSet(se, pattern = "^RPS|^RPL", col.name = "perc.ribo")
# Calculate the percentage of hemoglobin genes
se <- PercentageFeatureSet(se, pattern = "^HB[^(P)]", col.name = "perc.hb")# Plot Percent of mitochondrial genes by Sample
VlnPlot(se,
group.by = "Sample ID",
features = "perc.mt",
# log = TRUE,
pt.size = 0,
) + NoLegend() +
scale_color_manual(values = pal)
# Plot Percent of ribosomal genes by Sample
VlnPlot(se,
group.by = "Sample ID",
features = "perc.ribo",
# log = TRUE,
pt.size = 0
) + NoLegend() +
scale_color_manual(values = pal)
# Plot Percent of hemoglobin genes by Sample
VlnPlot(se,
group.by = "Sample ID",
features = "perc.hb",
# log = TRUE,
pt.size = 0
) + NoLegend() +
scale_color_manual(values = pal)
# Plot features by Sample together
VlnPlot(se,
group.by = "Sample ID",
features = c("perc.mt", "perc.ribo", "perc.hb"),
# log = TRUE,
pt.size = 0
) + NoLegend() +
scale_color_manual(values = pal)
With these distributions, something notable is going on in Flu 5. Let’s perform other quality control visualizations to see if we can find out what is happening.
# Comparison of mitochondrial and hemoglobin genes
p1 <- se@meta.data %>%
ggplot2::ggplot(., ggplot2::aes(x = perc.mt, y = perc.hb, color = Celltype)) +
ggplot2::geom_point() +
ggplot2::theme_classic()
p2 <- se@meta.data %>%
ggplot2::ggplot(., ggplot2::aes(x = perc.mt, y = perc.hb, color = donor_id)) +
ggplot2::geom_point() +
ggplot2::theme_classic()
p1 | p2
Plotting the hemoglobin genes by mitochondrial genes shows that the Flu 5 has low mitochondria and high hemoglobin suggesting its sample contained a lot of blood and is not poor quality.
Feature Covariation
TKTK This style plot colors by a specified variable in order to see its prevalence across the data. Below, the distribution of mitochondrial percentage across the dataset is shown in relation to the library size.
# Percent Mitochondrial Genes
se@meta.data %>%
ggplot2::ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = perc.mt)) +
ggplot2::geom_point() +
ggplot2::theme_classic() +
ggplot2::scale_color_gradient(low = "yellow", high = "red", limits = c(0, 20))
# Percent MT Genes per sample
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = perc.mt)) +
geom_point() +
facet_wrap(~`Sample ID`) +
theme_classic() +
scale_color_gradient(low = "yellow", high = "red", limits = c(0, 20)) +
scale_x_continuous(
labels = scales::unit_format(unit = "K", scale = 1e-3))
The authors mention they filter out UMIs with higher than 15% mitochondrial genes. This explains the cap we see at that range above.
Below we look at teh distribution of ribosomal expression which can be helpful as they can be more prevalent in tumor cells.
# Percent Ribosomal Genes
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = perc.ribo)) +
geom_point() +
theme_classic() +
scale_color_gradient(low = "yellow", high = "red")
# Percent MT Genes per sample
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = perc.ribo)) +
geom_point() +
facet_wrap(~`Sample ID`) +
theme_classic() +
scale_color_gradient(low = "yellow", high = "red") +
scale_x_continuous(
labels = scales::unit_format(unit = "K", scale = 1e-3))
Lastly, let’s plot the hemoglobin distribution and investigate the likely bloodier samples.
# Percent Hemoglobin Genes
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = perc.hb)) +
geom_point() +
theme_classic() +
scale_color_gradient(low = "yellow", high = "red", limits = c(0, 100))
# Percent hemoglobin Genes per sample
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = perc.hb)) +
geom_point() +
facet_wrap(~`Sample ID`) +
theme_classic() +
scale_color_gradient(low = "yellow", high = "red", limits = c(0, 100)) +
scale_x_continuous(
labels = scales::unit_format(unit = "K", scale = 1e-3))
The odd distribution of Flu 5 makes more sense seeing its high hemoglobin content with lower cell counts. Let’s plot the cell type annotations to see how they support this.
# Plot by cell type
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = Celltype)) +
geom_point() +
theme_classic() +
scale_color_manual(values = pal)
# Percent MT Genes per sample
se@meta.data %>%
ggplot(., ggplot2::aes(x = nCount_RNA, y = nFeature_RNA, color = Celltype)) +
geom_point() +
facet_wrap(~Celltype) +
theme_classic() +
scale_color_manual(values = pal)
After looking at the cell type distribution, the hemoglobin concentration makes sense as it corresponds to erythocytes which are high in hemoglobin.
Add Batch Information
Preprocessed Seurat object’s will often contain batch and sample informatio as well as how doublets were calculated. From the paper for this dataset, the batch information is found in a supplementary table and the authors claimed most doublets were classified as “Uncategorized”. Because they did not include the doublet information in the metadata, we will add it in this section.
Packages to find doublets in both R and Python run one batch at a time as doublets are only a source of error at the 10X run level. We imported the batch information so we could subset the larger object and filter out doublets per batch.
# Make a data frame and extract barcode and Sample ID metadata from se obj
info <- data.frame(Barcode = colnames(se), "Sample ID" = se@meta.data$'Sample ID')
colnames(info) <- gsub("\\.", " ", colnames(info))
# Load in batch information
batch_info <- read.csv("../data/batch_info.csv")
# Rename batch_info column names to have a space instead of "."
colnames(batch_info) <- gsub("\\.", " ", colnames(batch_info))
batch_info <- batch_info %>%
select("Sample ID", "Experimental batch")
head(batch_info) Sample ID Experimental batch
1 Flu 1 1
2 Flu 2 1
3 Flu 3 2
4 Flu 4 2
5 Flu 5 2
6 nCoV 1 1# merge the batch_info with the info dataframe
info <- merge(info, batch_info, by = "Sample ID")
rownames(info) <- info$Barcode
info <- info %>% select(-Barcode)
# Add batch numbers to the metadata
se <- AddMetaData(se, info)DoubletFinder
Doublet detection and removal is sensitive because you don’t want to remove any valuable outliers but still take into consideration the noisiness of the data. There are many different packages that can be used to detect doublets. If you are familiar with Python, we use Scrublet most often. But for the sake of staying in one programming language, DoubletFinder was found to be one of the most accurate R packages. DoubletFinder uses a nearest neighbor approach to identify doublets. The package has a function called doubletFinder that takes in a Seurat object and returns a Seurat object with doublet information added in the metadata.
How it Works
TKTK DoubletFinder looks at the expression profiles of cells in a batch and generates two parameters (pK & pANN) to identify doublets. DoubletFinder combines random cell’s gene expression profiles to create “fake doublets.” The artificial doublets are inserted into the data and their expression profiles are compared to the real cells to determine which cells are real doublets. This is done by a k-nearest neighbors graph where the best pK is surveyed and calculated for each batch.
Here, you have a k-nearest neighbor graph where each cell has k most-genetically-similar neighbors. pANN is the proportion of each cell’s neighbors that are artificial. A high pANN value says that a larger proportion of the cells around a specific cell in the kNN graph are fake doublets which suggests that the cell itself is a doublet. The higher the pK, the higher the pANN needs to be to make a difference.
Cells in transitioning states or cells with mixed phenotpyes can be mistaken for doublets. It is important not to disgard cells just because they have a large doublet score (pANN value) because there might be interesting biological information in these cells.
DoubletFinder allows you to set a threshold and will give each cell a categorical result of ‘Singlet’ or ‘Doublet’ but we suggest looking at the raw pANN values to understand the distribution of these cells and make threshold adjustments accordingly.
Parameters
pK parameter = the expected proportion of doublets in our dataset. This metric determines the accuracy of the model. The higher the pK, the more stringent the model is in classifying doublets. The lower the pK, the more lenient the model is in classifying doublets. pK is the PC neighborhood size that is used to compute pANN, and it is expressed as a proportion of the merged real-artificial data.
pN parameter = default number of doublets we expect to find (default = 0.25). pN functions as the threshold.
pANN = proportion of artificial nearest neighbors or the “doublet score”.
Note: DoubletFinder is only sensitive to heterotypic doublets (transcriptionally-distinct doublets) so the developer suggests using a cell-type annotations (here: batch_seurat_object@meta.data$seurat_clusters) to model the expected proportion of homotypic (transcriptionally-similar) doublets.
library(DoubletFinder)
exp_btch <- unique(se@meta.data$'Experimental batch')# Run doubletFinder
process_batch <- function(batch) {
print(batch)
# 0 - correct for one of the batches
# 1 - Subset Seurat object by batch
batch_seurat_object <- subset(se, cells = which(se@meta.data$'Experimental batch' == batch))
# 2 - Process count data of that subseted Seurat object
batch_seurat_object <- batch_seurat_object %>%
NormalizeData() %>%
FindVariableFeatures() %>%
ScaleData() %>%
RunPCA() %>%
FindNeighbors() %>%
FindClusters()
# 3 - nExp defines the expected pANN threshold used to make final doublet-decisions
annotations <- batch_seurat_object@meta.data$seurat_clusters
homotypic.prop <- modelHomotypic(annotations)
nExp_poi <- round(0.075*nrow(se@meta.data)) # Assuming 7.5% doublet formation rate
nExp_poi.adj <- round(nExp_poi*(1-homotypic.prop))
# 6 - Run doubletFinder
batch_seurat_object <- doubletFinder(
batch_seurat_object,
PCs = 1:20,
pN = 0.1,
pK = 50 / ncol(batch_seurat_object), # set a k to aproximately 50 cells per neighborhood for pANN
nExp = nExp_poi.adj,
reuse.pANN = FALSE, # If TRUE, pANN will be reused from a previous run
sct = FALSE) # If TRUE, sctransform will be used for preprocessing
# 7 - Format doublet information for return dataframe
pANN <- colnames(batch_seurat_object@meta.data) %>%
keep(grepl('^pANN*', colnames(batch_seurat_object@meta.data))) # pANN_0.25_0.3_1000
DF_class <- colnames(batch_seurat_object@meta.data) %>%
keep(grepl('^DF.classifications*', colnames(batch_seurat_object@meta.data))) # DF.classifications_0.25_0.3_1000
## Extract values from pANN variable name
params <- gsub("^pANN_", "", pANN) # Remove "pANN_"
params <- strsplit(params, "_")[[1]] # Split by "_"
pN <- params[1] # Extract "0.1"
pK <- params[2] # Extract "0.1"
doublet_run <- params[3] # Extract "1000"
## Create new columns "pN", "pK", and "doublet_run"
colnames(batch_seurat_object@meta.data)[colnames(batch_seurat_object@meta.data) == pANN] <- "pANN"
colnames(batch_seurat_object@meta.data)[colnames(batch_seurat_object@meta.data) == DF_class] <- "DF_class"
batch_seurat_object@meta.data$pN <- pN
batch_seurat_object@meta.data$pK <- pK
batch_seurat_object@meta.data$doublet_run <- doublet_run
# 8 - Return DF of doublet information here
df <- data.frame(
Barcode = colnames(batch_seurat_object),
batch = batch_seurat_object@meta.data$'Experimental batch',
pANN = batch_seurat_object@meta.data$'pANN',
DF_class = batch_seurat_object@meta.data$'DF_class',
doublet_run = batch_seurat_object@meta.data$doublet_run,
pK = batch_seurat_object@meta.data$pK,
pN = batch_seurat_object@meta.data$pN
)
rownames(df) <- df$Barcode
return(df)
}
processed_doublets <- lapply(exp_btch, process_batch)[1] 3
Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 18752
Number of edges: 616465
Running Louvain algorithm...
Maximum modularity in 10 random starts: 0.9052
Number of communities: 19
Elapsed time: 2 seconds
[1] "Creating 2084 artificial doublets..."
[1] "Creating Seurat object..."
[1] "Normalizing Seurat object..."
[1] "Finding variable genes..."
[1] "Scaling data..."
[1] "Running PCA..."
[1] "Calculating PC distance matrix..."
[1] "Computing pANN..."
[1] "Classifying doublets.."
[1] 4
Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 16507
Number of edges: 535537
Running Louvain algorithm...
Maximum modularity in 10 random starts: 0.9040
Number of communities: 22
Elapsed time: 1 seconds
[1] "Creating 1834 artificial doublets..."
[1] "Creating Seurat object..."
[1] "Normalizing Seurat object..."
[1] "Finding variable genes..."
[1] "Scaling data..."
[1] "Running PCA..."
[1] "Calculating PC distance matrix..."
[1] "Computing pANN..."
[1] "Classifying doublets.."
[1] 2
Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 8624
Number of edges: 286940
Running Louvain algorithm...
Maximum modularity in 10 random starts: 0.8967
Number of communities: 19
Elapsed time: 0 seconds
[1] "Creating 958 artificial doublets..."
[1] "Creating Seurat object..."
[1] "Normalizing Seurat object..."
[1] "Finding variable genes..."
[1] "Scaling data..."
[1] "Running PCA..."
[1] "Calculating PC distance matrix..."
[1] "Computing pANN..."
[1] "Classifying doublets.."
[1] 1
Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 15689
Number of edges: 524420
Running Louvain algorithm...
Maximum modularity in 10 random starts: 0.9105
Number of communities: 21
Elapsed time: 1 seconds
[1] "Creating 1743 artificial doublets..."
[1] "Creating Seurat object..."
[1] "Normalizing Seurat object..."
[1] "Finding variable genes..."
[1] "Scaling data..."
[1] "Running PCA..."
[1] "Calculating PC distance matrix..."
[1] "Computing pANN..."
[1] "Classifying doublets.."# Add doublet information to the main seurat object
test <- bind_rows(processed_doublets)rownames(test) <- test$Barcode
test <- test %>% select(-Barcode)
se <- AddMetaData(
object = se,
metadata = test
)# Save Doublet information in Seurat object
saveRDS(se, '../data/Covid_Flu_Seurat_Object_DF.rds')Load Pre-Run DF object
se <- readRDS('../data/Covid_Flu_Seurat_Object_DF.rds')Perform Preprocessing
se <- se %>%
NormalizeData(verbose = FALSE) %>%
FindVariableFeatures(
method = "vst",
nfeatures = 3000,
verbose = FALSE) %>%
ScaleData(verbose = FALSE, features = VariableFeatures(.)) %>%
RunPCA(verbose = FALSE) %>%
FindNeighbors() %>%
FindClusters(resolution = 0.05) %>%
RunUMAP(dims = 1:30, verbose = FALSE)Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 59572
Number of edges: 1894745
Running Louvain algorithm...
Maximum modularity in 10 random starts: 0.9829
Number of communities: 7
Elapsed time: 15 seconds# Plot UMAP colored by batch
DimPlot(se, reduction = "umap", group.by = 'DF_class') +
labs(title = "UMAP Plot Colored by Doublet Class")
Let’s look at the distribution of pANN values
# Plot UMAP by pANN
p1 <- FeaturePlot(se, reduction = "umap", features = "pANN") +
labs(title = "UMAP Plot Colored by pANN")
# Plot UMAP by cell type
p2 <- DimPlot(se, reduction = "umap", group.by = "Celltype") +
labs(title = "UMAP Plot Colored by Cell Type") +
scale_color_manual(values = pal)
p1 | p2
# DimPlot(se, reduction = "umap", group.by = "Celltype") +
# labs(title = "UMAP Plot Colored by Batch")Let’s see if celltypes annotated by the authors are show the pANN distribution.
if (!requireNamespace("ggridges", quietly = TRUE)) {
install.packages("ggridges")
}
library(ggridges)
# Assuming se@meta.data is your data frame
ggplot(se@meta.data, aes(x = pANN, y = Celltype, fill = Celltype)) +
geom_density_ridges(alpha = 0.5) +
theme_classic() +
scale_color_manual(values = pal)
Filter out cells
Filter out our data by 4 criteria.
Any cell with less that 500 UMIs
Any cell with less than 200 genes
Any cell with more than 15% mitochondrial genes
se@meta.data <- se@meta.data %>%
mutate(
quality = if_else(nFeature_RNA > 200 & nCount_RNA > 500 & perc.mt < 15, "good quality", "bad quality"),
quality = factor(quality, levels = c("bad quality", "good quality"))
)s2 <- FeaturePlot(se, reduction = "umap", features = "pANN") +
labs(title = "UMAP Plot Colored by pANN") +
scale_fill_gradient(limits = c(0, 1))
# Plot UMAP of good quality cells
s3 <- DimPlot(se, reduction = "umap", group.by = "quality") +
labs(title = "UMAP Plot Colored by Cell Quality")
s4 <- DimPlot(se, reduction = "umap", group.by = "Celltype") +
labs(title = "UMAP Plot Colored by Cell Type") +
scale_color_manual(values = pal)
s2 | s3 | s4
Lack of overlap between pANN dist and doublet dist is good because odds of a doublet of two poor quality cells is low.
We will keep the potential doublets in the data because they may be biologically relevant.
Differential Gene Expression comparison between good and bad quality cells
# 1 - Perform differential gene expression on se@meta.data$quality = good and bad
Idents(se) <- se$quality
mgs <- FindMarkers(
se,
ident.1 = "bad quality",
ident.2 = "good quality",
test.use = "wilcox",
slot = "data",
logfc.threshold = 0.25,
min.pct = 0.25)
mgs <- mgs %>%
rownames_to_column("gene") %>%
mutate(
gene_type = case_when(
str_detect(gene, pattern = "^MT-") ~ "mt",
str_detect(gene, pattern = "^RPS|^RPL") ~ "rb",
str_detect(gene, pattern = "^HB[^(P)]") ~ "hb",
TRUE ~ "other"
)
)
mgs gene p_val avg_log2FC pct.1 pct.2 p_val_adj gene_type
1 RPS10 0.000000e+00 -2.0913895 0.072 0.868 0.000000e+00 rb
2 RPS21 0.000000e+00 -2.0137987 0.115 0.902 0.000000e+00 rb
3 RPL31 0.000000e+00 -1.6831092 0.074 0.858 0.000000e+00 rb
4 TOMM7 0.000000e+00 -1.6797877 0.060 0.839 0.000000e+00 other
5 RPL38 0.000000e+00 -1.7606579 0.119 0.897 0.000000e+00 rb
6 COX7C 0.000000e+00 -1.1037346 0.096 0.856 0.000000e+00 other
7 COMMD6 0.000000e+00 -1.7282373 0.041 0.789 0.000000e+00 other
8 RPL23 0.000000e+00 -1.2237581 0.134 0.880 0.000000e+00 rb
9 HNRNPA1 0.000000e+00 -1.1421124 0.103 0.843 0.000000e+00 other
10 DDX5 0.000000e+00 -0.8216554 0.166 0.896 0.000000e+00 other
11 RPL27 0.000000e+00 -1.2344377 0.176 0.906 0.000000e+00 rb
12 EEF2 0.000000e+00 -0.9603728 0.120 0.850 0.000000e+00 other
13 UQCRB 0.000000e+00 -0.7130181 0.119 0.848 0.000000e+00 other
14 RPS20 0.000000e+00 -1.2005717 0.169 0.895 0.000000e+00 rb
15 CD48 0.000000e+00 -0.9325543 0.094 0.817 0.000000e+00 other
16 PNISR 0.000000e+00 -1.2632073 0.059 0.781 0.000000e+00 other
17 BTG1 0.000000e+00 -1.3751895 0.160 0.882 0.000000e+00 other
18 BTF3 0.000000e+00 -0.6948830 0.171 0.893 0.000000e+00 other
19 SRSF5 0.000000e+00 -0.7764157 0.088 0.808 0.000000e+00 other
20 CD37 0.000000e+00 -1.1098446 0.107 0.827 0.000000e+00 other
21 EEF1B2 0.000000e+00 -1.1516194 0.155 0.875 0.000000e+00 other
22 RPL27A 0.000000e+00 -1.2182378 0.178 0.898 0.000000e+00 rb
23 TMA7 0.000000e+00 -0.4048852 0.160 0.880 0.000000e+00 other
24 ATP5MC2 0.000000e+00 -0.5842837 0.133 0.851 0.000000e+00 other
25 HINT1 0.000000e+00 -0.7213765 0.101 0.819 0.000000e+00 other
26 RPL35 0.000000e+00 -1.1612309 0.190 0.904 0.000000e+00 rb
27 PNRC1 0.000000e+00 -0.7560853 0.086 0.795 0.000000e+00 other
28 RBM39 0.000000e+00 -0.4949071 0.116 0.824 0.000000e+00 other
29 RPL36AL 0.000000e+00 -0.4620919 0.178 0.885 0.000000e+00 rb
30 RPS29 0.000000e+00 -2.1757463 0.222 0.929 0.000000e+00 rb
31 JUND 0.000000e+00 -1.2972509 0.206 0.912 0.000000e+00 other
32 ATP5MG 0.000000e+00 -0.3827306 0.169 0.875 0.000000e+00 other
33 SRRM2 0.000000e+00 -0.6633327 0.078 0.783 0.000000e+00 other
34 SON 0.000000e+00 -0.7944571 0.070 0.774 0.000000e+00 other
35 RPL36 0.000000e+00 -1.4542507 0.216 0.919 0.000000e+00 rb
36 LIMD2 0.000000e+00 -0.9381949 0.073 0.775 0.000000e+00 other
37 EIF3K 0.000000e+00 -0.3555461 0.123 0.824 0.000000e+00 other
38 RPL22 0.000000e+00 -1.2591953 0.217 0.915 0.000000e+00 rb
39 RPLP0 0.000000e+00 -0.8214933 0.189 0.887 0.000000e+00 rb
40 NOP53 0.000000e+00 -1.4182918 0.054 0.752 0.000000e+00 other
41 EIF3F 0.000000e+00 -0.8199362 0.072 0.769 0.000000e+00 other
42 PTPRC 0.000000e+00 -0.4620036 0.166 0.862 0.000000e+00 other
43 SF1 0.000000e+00 -0.8277718 0.079 0.774 0.000000e+00 other
44 TXNIP 0.000000e+00 -1.1395119 0.182 0.877 0.000000e+00 other
45 CCNI 0.000000e+00 -0.2771694 0.150 0.845 0.000000e+00 other
46 COX6C 0.000000e+00 -0.6556729 0.081 0.775 0.000000e+00 other
47 ZFP36L2 0.000000e+00 -1.1608645 0.111 0.803 0.000000e+00 other
48 RBM3 0.000000e+00 -0.7421138 0.065 0.757 0.000000e+00 other
49 SARAF 0.000000e+00 -0.7685619 0.110 0.801 0.000000e+00 other
50 HNRNPDL 0.000000e+00 -0.6233054 0.081 0.771 0.000000e+00 other
51 TLE5 0.000000e+00 -1.0257535 0.088 0.777 0.000000e+00 other
52 CIRBP 0.000000e+00 -0.5279448 0.115 0.803 0.000000e+00 other
53 RPL10A 0.000000e+00 -1.2690747 0.214 0.902 0.000000e+00 rb
54 PSME1 0.000000e+00 -0.5093006 0.107 0.794 0.000000e+00 other
55 RPL26 0.000000e+00 -1.8943796 0.240 0.927 0.000000e+00 rb
56 SLC25A6 0.000000e+00 -0.4110531 0.146 0.833 0.000000e+00 other
57 RPS25 0.000000e+00 -1.6351228 0.243 0.928 0.000000e+00 rb
58 CD52 0.000000e+00 -1.5581675 0.094 0.778 0.000000e+00 other
59 RPL23A 0.000000e+00 -1.7824790 0.237 0.921 0.000000e+00 rb
60 RPS5 0.000000e+00 -1.0419682 0.214 0.895 0.000000e+00 rb
61 FUS 0.000000e+00 -0.7198315 0.079 0.759 0.000000e+00 other
62 NPM1 0.000000e+00 -0.5587635 0.111 0.791 0.000000e+00 other
63 RPS26 0.000000e+00 -1.0393721 0.186 0.866 0.000000e+00 rb
64 COX7A2 0.000000e+00 -0.5099730 0.072 0.750 0.000000e+00 other
65 RPL37A 0.000000e+00 -1.3623921 0.246 0.924 0.000000e+00 rb
66 PRRC2C 0.000000e+00 -0.6438354 0.074 0.747 0.000000e+00 other
67 EIF3E 0.000000e+00 -1.0516082 0.058 0.730 0.000000e+00 other
68 RPSA 0.000000e+00 -1.0682307 0.233 0.904 0.000000e+00 rb
69 ELOB 0.000000e+00 -0.3128467 0.122 0.791 0.000000e+00 other
70 KLF2 0.000000e+00 -1.3307575 0.093 0.760 0.000000e+00 other
71 PCBP2 0.000000e+00 -0.4965579 0.096 0.763 0.000000e+00 other
72 RPL5 0.000000e+00 -1.2687526 0.252 0.917 0.000000e+00 rb
73 HNRNPU 0.000000e+00 -0.4367136 0.086 0.751 0.000000e+00 other
74 SRRM1 0.000000e+00 -1.0139357 0.046 0.711 0.000000e+00 other
75 EDF1 0.000000e+00 -0.2897948 0.090 0.753 0.000000e+00 other
76 LSP1 0.000000e+00 -1.1335846 0.055 0.717 0.000000e+00 other
77 SSR2 0.000000e+00 -0.5891299 0.068 0.728 0.000000e+00 other
78 RPLP2 0.000000e+00 -1.5774281 0.277 0.936 0.000000e+00 rb
79 EIF3H 0.000000e+00 -0.6151107 0.065 0.718 0.000000e+00 other
80 SAP18 0.000000e+00 -0.2553228 0.081 0.734 0.000000e+00 other
81 HNRNPA3 0.000000e+00 -0.4041266 0.080 0.732 0.000000e+00 other
82 ARL6IP4 0.000000e+00 -0.6927608 0.057 0.707 0.000000e+00 other
83 SET 0.000000e+00 -0.3955327 0.084 0.733 0.000000e+00 other
84 VAMP2 0.000000e+00 -0.8901431 0.053 0.699 0.000000e+00 other
85 ERP29 0.000000e+00 -0.3128825 0.084 0.728 0.000000e+00 other
86 TCF25 0.000000e+00 -0.6081954 0.063 0.706 0.000000e+00 other
87 TAPBP 0.000000e+00 -0.7588811 0.060 0.702 0.000000e+00 other
88 EIF3G 0.000000e+00 -0.2713094 0.075 0.715 0.000000e+00 other
89 RPL3 0.000000e+00 -1.3438559 0.280 0.918 0.000000e+00 rb
90 CD44 0.000000e+00 -0.8352935 0.088 0.725 0.000000e+00 other
91 NCL 0.000000e+00 -0.8738276 0.053 0.690 0.000000e+00 other
92 CD74 0.000000e+00 -1.4339428 0.188 0.824 0.000000e+00 other
93 SFPQ 0.000000e+00 -0.5797824 0.062 0.695 0.000000e+00 other
94 HLA-DPB1 0.000000e+00 -1.8566252 0.065 0.698 0.000000e+00 other
95 STK4 0.000000e+00 -0.2551091 0.086 0.716 0.000000e+00 other
96 RPL35A 0.000000e+00 -1.2277631 0.320 0.949 0.000000e+00 rb
97 HLA-DPA1 0.000000e+00 -1.7080824 0.070 0.699 0.000000e+00 other
98 EIF3L 0.000000e+00 -1.3703708 0.034 0.661 0.000000e+00 other
99 RPL21 0.000000e+00 -1.4207376 0.324 0.948 0.000000e+00 rb
100 RPL34 0.000000e+00 -1.8007005 0.315 0.938 0.000000e+00 rb
101 ANKRD12 0.000000e+00 -1.3745733 0.041 0.663 0.000000e+00 other
102 RPS28 0.000000e+00 -1.6536380 0.316 0.938 0.000000e+00 rb
103 STK17B 0.000000e+00 -0.5476391 0.062 0.682 0.000000e+00 other
104 RPS15A 0.000000e+00 -1.7002797 0.324 0.944 0.000000e+00 rb
105 RAC2 0.000000e+00 -0.2615227 0.089 0.708 0.000000e+00 other
106 RPL37 0.000000e+00 -1.6525941 0.318 0.937 0.000000e+00 rb
107 KMT2E 0.000000e+00 -0.8510909 0.049 0.666 0.000000e+00 other
108 SRSF7 0.000000e+00 -0.6455855 0.060 0.675 0.000000e+00 other
109 DDX17 0.000000e+00 -0.4320045 0.063 0.676 0.000000e+00 other
110 HIGD2A 0.000000e+00 -0.4664875 0.068 0.681 0.000000e+00 other
111 RPL36A 0.000000e+00 -1.2370431 0.037 0.649 0.000000e+00 rb
112 EIF5A 0.000000e+00 -0.3038650 0.073 0.684 0.000000e+00 other
113 EIF4B 0.000000e+00 -0.9200344 0.045 0.656 0.000000e+00 other
114 SNRPD2 0.000000e+00 -1.2128888 0.033 0.643 0.000000e+00 other
115 APRT 0.000000e+00 -0.4614036 0.062 0.670 0.000000e+00 other
116 N4BP2L2 0.000000e+00 -1.0335641 0.039 0.647 0.000000e+00 other
117 ACTR2 0.000000e+00 -0.4128657 0.079 0.686 0.000000e+00 other
118 CAST 0.000000e+00 -0.3584160 0.081 0.687 0.000000e+00 other
119 DDX3X 0.000000e+00 -0.4115116 0.067 0.673 0.000000e+00 other
120 ICAM3 0.000000e+00 -0.7938164 0.047 0.651 0.000000e+00 other
121 PPP2R5C 0.000000e+00 -1.1841767 0.051 0.655 0.000000e+00 other
122 HNRNPH1 0.000000e+00 -0.3059294 0.075 0.678 0.000000e+00 other
123 ARF6 0.000000e+00 -1.2490981 0.034 0.636 0.000000e+00 other
124 SYF2 0.000000e+00 -0.5857649 0.054 0.655 0.000000e+00 other
125 AHNAK 0.000000e+00 -1.0498486 0.058 0.659 0.000000e+00 other
126 RPS8 0.000000e+00 -1.2687393 0.330 0.931 0.000000e+00 rb
127 MZT2B 0.000000e+00 -0.6485882 0.050 0.651 0.000000e+00 other
128 HLA-F 0.000000e+00 -0.2780481 0.083 0.683 0.000000e+00 other
129 ATP5ME 0.000000e+00 -0.4743448 0.058 0.658 0.000000e+00 other
130 UBXN1 0.000000e+00 -0.3168570 0.063 0.662 0.000000e+00 other
131 AKAP13 0.000000e+00 -0.6302514 0.053 0.651 0.000000e+00 other
132 HSPA5 0.000000e+00 -0.8979692 0.056 0.653 0.000000e+00 other
133 RBM25 0.000000e+00 -0.7283929 0.048 0.642 0.000000e+00 other
134 RPL39 0.000000e+00 -1.6660546 0.346 0.940 0.000000e+00 rb
135 HSPA8 0.000000e+00 -0.5322465 0.070 0.663 0.000000e+00 other
136 IQGAP1 0.000000e+00 -0.5063675 0.069 0.662 0.000000e+00 other
137 ARGLU1 0.000000e+00 -0.7792858 0.042 0.632 0.000000e+00 other
138 TOMM20 0.000000e+00 -0.8139692 0.042 0.632 0.000000e+00 other
139 PNN 0.000000e+00 -0.9995703 0.042 0.630 0.000000e+00 other
140 GSTK1 0.000000e+00 -0.4666511 0.063 0.650 0.000000e+00 other
141 RPL17 0.000000e+00 -2.6524740 0.012 0.598 0.000000e+00 rb
142 RPS23 0.000000e+00 -1.4705920 0.348 0.933 0.000000e+00 rb
143 CD81 0.000000e+00 -1.4257581 0.034 0.619 0.000000e+00 other
144 SERBP1 0.000000e+00 -0.3172182 0.062 0.646 0.000000e+00 other
145 SEC61G 0.000000e+00 -0.3808750 0.056 0.640 0.000000e+00 other
146 SPCS1 0.000000e+00 -0.2699236 0.060 0.643 0.000000e+00 other
147 EIF4A2 0.000000e+00 -0.7089377 0.044 0.622 0.000000e+00 other
148 HNRNPM 0.000000e+00 -0.7689365 0.037 0.611 0.000000e+00 other
149 REL 0.000000e+00 -0.7627547 0.054 0.627 0.000000e+00 other
150 RSL24D1 0.000000e+00 -0.8811758 0.034 0.606 0.000000e+00 other
151 DDX24 0.000000e+00 -0.9669352 0.040 0.610 0.000000e+00 other
152 RBM8A 0.000000e+00 -0.4489259 0.049 0.619 0.000000e+00 other
153 RPS18 0.000000e+00 -1.3218255 0.362 0.931 0.000000e+00 rb
154 NSA2 0.000000e+00 -1.0283320 0.032 0.600 0.000000e+00 other
155 RPS27 0.000000e+00 -2.1449161 0.382 0.950 0.000000e+00 rb
156 ARID4B 0.000000e+00 -0.8052063 0.041 0.608 0.000000e+00 other
157 NDUFB2 0.000000e+00 -0.9265408 0.039 0.604 0.000000e+00 other
158 EIF3M 0.000000e+00 -0.8617348 0.032 0.587 0.000000e+00 other
159 KRT10 0.000000e+00 -0.9859828 0.031 0.586 0.000000e+00 other
160 COPS9 0.000000e+00 -0.9573065 0.032 0.584 0.000000e+00 other
161 RPL30 0.000000e+00 -1.6243878 0.395 0.944 0.000000e+00 rb
162 IKZF1 0.000000e+00 -1.0441047 0.033 0.582 0.000000e+00 other
163 RPS3A 0.000000e+00 -1.2008215 0.394 0.940 0.000000e+00 rb
164 RPL32 0.000000e+00 -1.4285122 0.401 0.941 0.000000e+00 rb
165 RPS12 0.000000e+00 -1.5897422 0.425 0.954 0.000000e+00 rb
166 RPS27A 0.000000e+00 -1.4110549 0.436 0.952 0.000000e+00 rb
167 RPS14 0.000000e+00 -1.1734459 0.427 0.943 0.000000e+00 rb
168 RPL41 0.000000e+00 -1.5975458 0.497 0.964 0.000000e+00 rb
169 MT-ND3 0.000000e+00 -1.2132691 0.511 0.971 0.000000e+00 mt
170 RPL10 0.000000e+00 -1.3464548 0.531 0.956 0.000000e+00 rb
171 EEF1A1 0.000000e+00 -1.4642202 0.568 0.959 0.000000e+00 other
172 RPLP1 0.000000e+00 -1.0903025 0.592 0.965 0.000000e+00 rb
173 MALAT1 0.000000e+00 -1.1512627 0.819 0.983 0.000000e+00 other
174 SCAF11 2.747124e-307 -0.2982019 0.062 0.639 9.129791e-303 other
175 BZW1 3.280426e-307 -0.3431132 0.057 0.629 1.090217e-302 other
176 UXT 5.575060e-307 -0.4499888 0.052 0.618 1.852815e-302 other
177 GTF3A 1.141948e-306 -0.3507745 0.056 0.625 3.795151e-302 other
178 FAM133B 1.498386e-306 -0.6285549 0.049 0.611 4.979736e-302 other
179 ANAPC16 4.024030e-306 -0.6133168 0.042 0.598 1.337346e-301 other
180 DDX6 5.789723e-306 -0.9840550 0.039 0.592 1.924157e-301 other
181 SEC62 1.479330e-305 -0.5329020 0.055 0.620 4.916406e-301 other
182 RPS16 1.221113e-301 -1.2443450 0.290 0.926 4.058246e-297 rb
183 BCLAF1 2.506196e-301 -0.5282367 0.051 0.609 8.329090e-297 other
184 TUBA1A 2.561561e-301 -0.6424412 0.056 0.620 8.513091e-297 other
185 PPP1CA 4.654029e-301 -0.3016293 0.075 0.657 1.546720e-296 other
186 CRIP1 5.895350e-301 -1.9520390 0.020 0.548 1.959261e-296 other
187 RPS24 9.442758e-300 -1.0484417 0.394 0.941 3.138206e-295 rb
188 IER2 1.103480e-299 -0.3539144 0.115 0.730 3.667306e-295 other
189 RPS19 5.483798e-299 -1.2530809 0.384 0.935 1.822485e-294 rb
190 LSM7 6.933533e-299 -0.7678861 0.033 0.572 2.304290e-294 other
191 PCSK7 1.331137e-297 -1.2420953 0.031 0.567 4.423901e-293 other
192 EZR 3.185723e-297 -1.2516576 0.033 0.570 1.058743e-292 other
193 NDUFB8 5.520588e-297 -0.5748994 0.038 0.580 1.834712e-292 other
194 C9orf78 3.278806e-295 -0.9895570 0.034 0.568 1.089679e-290 other
195 JUNB 7.888461e-295 -0.7098276 0.171 0.826 2.621651e-290 other
196 EVL 1.008129e-293 -1.6742888 0.031 0.561 3.350416e-289 other
197 SMDT1 4.528833e-293 -0.2935841 0.063 0.626 1.505112e-288 other
198 FNBP1 4.790085e-293 -1.3105433 0.024 0.548 1.591937e-288 other
199 TMEM258 1.264090e-292 -0.5301614 0.045 0.589 4.201075e-288 other
200 SF3B2 3.140012e-292 -0.2751193 0.052 0.602 1.043551e-287 other
201 KLF6 3.187219e-292 -0.3225033 0.128 0.752 1.059241e-287 other
202 RPL9 8.085104e-291 -1.2006700 0.329 0.935 2.687003e-286 rb
203 SELENOK 9.584873e-291 -0.6382619 0.044 0.586 3.185437e-286 other
204 CCDC12 1.354357e-290 -0.9784557 0.025 0.548 4.501071e-286 other
205 RSRP1 5.427234e-290 -0.5483995 0.050 0.595 1.803687e-285 other
206 EPC1 3.284663e-289 -1.0017773 0.026 0.548 1.091625e-284 other
207 RPL4 2.160483e-288 -0.8760192 0.203 0.898 7.180149e-284 rb
208 ADGRE5 1.348485e-287 -0.7247066 0.051 0.596 4.481555e-283 other
209 CXCR4 2.018172e-287 -1.1642842 0.093 0.668 6.707192e-283 other
210 ZFP36 7.303508e-287 -0.4321995 0.112 0.711 2.427248e-282 other
211 UFC1 1.215256e-286 -0.6422282 0.040 0.572 4.038781e-282 other
212 RPS6 1.247723e-286 -1.1981703 0.312 0.922 4.146684e-282 rb
213 EIF3A 3.473285e-285 -0.5391760 0.043 0.576 1.154311e-280 other
214 ARHGEF1 8.266551e-285 -0.7008044 0.036 0.562 2.747305e-280 other
215 RPL6 2.363272e-284 -1.0822195 0.311 0.930 7.854099e-280 rb
216 HERPUD1 4.251738e-284 -0.6917031 0.054 0.596 1.413023e-279 other
217 ATP5IF1 5.708401e-284 -0.3352735 0.052 0.592 1.897130e-279 other
218 RPL11 9.417525e-283 -1.0145575 0.460 0.944 3.129820e-278 rb
219 UQCRQ 1.078458e-282 -0.8088219 0.031 0.550 3.584147e-278 other
220 SRSF11 1.880249e-281 -0.3343316 0.050 0.586 6.248820e-277 other
221 RPL28 2.228633e-281 -0.9543674 0.520 0.949 7.406638e-277 rb
222 HCST 2.458444e-281 -0.7043413 0.128 0.739 8.170394e-277 other
223 EIF4A1 3.323343e-281 -0.6301431 0.042 0.570 1.104480e-276 other
224 SNRPG 7.718710e-281 -1.0253187 0.025 0.536 2.565236e-276 other
225 RPL14 1.958721e-280 -1.1099918 0.296 0.925 6.509615e-276 rb
226 HNRNPA0 3.857330e-280 -1.3433001 0.021 0.527 1.281945e-275 other
227 TPT1 7.270789e-280 -0.9477577 0.631 0.976 2.416374e-275 other
228 CYTIP 6.330764e-279 -0.5981014 0.042 0.569 2.103966e-274 other
229 DDX21 5.525617e-278 -0.7663045 0.039 0.561 1.836384e-273 other
230 NKTR 2.073414e-277 -0.9242839 0.032 0.546 6.890783e-273 other
231 RPL13 3.114521e-276 -1.0602713 0.521 0.950 1.035080e-271 rb
232 PLAAT4 6.801585e-276 -1.4119962 0.032 0.545 2.260439e-271 other
233 EEF1D 9.861789e-276 -0.5644292 0.205 0.905 3.277467e-271 other
234 CUTA 5.782908e-275 -0.5160005 0.044 0.567 1.921892e-270 other
235 SEC11A 9.569041e-275 -0.3116109 0.051 0.580 3.180175e-270 other
236 ZBTB7A 1.673738e-274 -1.0723406 0.032 0.542 5.562501e-270 other
237 MORF4L1 3.232037e-274 0.2580614 0.117 0.713 1.074135e-269 other
238 RPS13 1.312215e-272 -1.1043385 0.347 0.932 4.361016e-268 rb
239 RPL13A 1.694730e-272 -1.1411764 0.353 0.934 5.632267e-268 rb
240 LUC7L3 1.634493e-271 -0.7560113 0.035 0.545 5.432073e-267 other
241 NDUFA11 1.635089e-271 -0.2726818 0.053 0.580 5.434055e-267 other
242 SEPTIN9 2.162287e-271 -0.4011916 0.046 0.566 7.186146e-267 other
243 RPS7 9.515091e-271 -1.0294586 0.332 0.935 3.162245e-266 rb
244 CDV3 1.401372e-270 -0.2562616 0.055 0.584 4.657320e-266 other
245 TRA2B 1.735677e-270 -0.3936739 0.049 0.571 5.768350e-266 other
246 EIF3D 5.092755e-268 -0.6465499 0.034 0.540 1.692526e-263 other
247 POLR2J3-ENSG00000285437 6.965814e-268 -0.8039291 0.031 0.533 2.315019e-263 other
248 SELENOH 7.823100e-268 -0.5765241 0.040 0.550 2.599929e-263 other
249 FYN 6.003050e-266 -0.9240667 0.039 0.546 1.995054e-261 other
250 ANXA1 7.414227e-266 -0.6500831 0.127 0.720 2.464044e-261 other
251 RPS3 7.889362e-266 -1.0793794 0.387 0.939 2.621951e-261 rb
252 POLR2L 5.924874e-265 -0.4905120 0.047 0.560 1.969073e-260 other
253 CLEC2B 3.528172e-264 -0.6821404 0.042 0.551 1.172553e-259 other
254 TRMT112 1.576428e-262 -0.4404212 0.037 0.538 5.239101e-258 other
255 ATP5MC3 4.866574e-262 0.3722032 0.095 0.654 1.617357e-257 other
256 RWDD1 8.083054e-262 -0.7275252 0.034 0.531 2.686322e-257 other
257 NDUFC2 8.530383e-262 -0.5235978 0.037 0.539 2.834988e-257 other
258 RNPS1 1.236492e-261 -0.6380319 0.033 0.529 4.109356e-257 other
259 MED10 7.107357e-261 -0.5153331 0.038 0.538 2.362059e-256 other
260 NSD3 8.472404e-261 -1.1201971 0.025 0.513 2.815719e-256 other
261 RUNX3 4.867870e-260 -1.7142061 0.026 0.514 1.617788e-255 other
262 SUN2 1.327962e-259 -1.2318107 0.023 0.507 4.413348e-255 other
263 ARL4C 1.396022e-259 -1.6419483 0.042 0.543 4.639539e-255 other
264 PSMD7 1.984831e-259 -0.4172508 0.037 0.535 6.596389e-255 other
265 ITGB2 2.611089e-259 -0.4814656 0.153 0.771 8.677693e-255 other
266 ANKRD44 1.239248e-258 -1.2494822 0.021 0.503 4.118515e-254 other
267 ARID1B 2.735684e-258 -1.1146025 0.027 0.513 9.091773e-254 other
268 GGNBP2 2.173288e-257 -0.5104171 0.037 0.534 7.222706e-253 other
269 RPS11 2.738400e-257 -1.0036456 0.263 0.926 9.100799e-253 rb
270 RPS2 4.967912e-257 -0.9330091 0.434 0.939 1.651036e-252 rb
271 NDUFA3 9.553623e-257 -0.8900735 0.029 0.515 3.175051e-252 other
272 KLF3 1.797064e-255 -0.5178497 0.050 0.556 5.972363e-251 other
273 FOXP1 3.562375e-255 -1.3118227 0.029 0.513 1.183920e-250 other
274 AAK1 3.844891e-255 -1.2535342 0.022 0.500 1.277811e-250 other
275 LSM8 1.762601e-254 -0.8752261 0.027 0.510 5.857829e-250 other
276 FAU 4.245656e-254 -1.0014261 0.392 0.944 1.411001e-249 other
277 RPL12 5.744456e-254 -1.0084270 0.325 0.933 1.909113e-249 rb
278 EIF5 1.159606e-253 0.2728711 0.090 0.633 3.853835e-249 other
279 CYLD 2.490086e-253 -0.7535527 0.030 0.513 8.275552e-249 other
280 DDT 2.773077e-250 -0.5230150 0.039 0.527 9.216043e-246 other
281 RPS15 3.508323e-250 -0.9830456 0.389 0.939 1.165956e-245 rb
282 SMCHD1 4.622719e-250 0.2998636 0.089 0.628 1.536314e-245 other
283 TAF1D 1.336525e-249 -0.9299621 0.030 0.509 4.441808e-245 other
284 EIF2S3 3.575146e-249 -0.6145576 0.033 0.514 1.188164e-244 other
285 MRPL54 4.593778e-249 -0.6368488 0.030 0.508 1.526696e-244 other
286 RBMX 7.239313e-249 -1.3210375 0.016 0.483 2.405913e-244 other
287 MIF 1.566386e-248 -1.1021344 0.023 0.496 5.205727e-244 other
288 ST13 1.595800e-248 -0.5636828 0.034 0.516 5.303483e-244 other
289 ATP6AP2 1.845368e-248 -0.3371790 0.044 0.535 6.132895e-244 other
290 SEPTIN7 5.105776e-248 0.2823462 0.144 0.740 1.696853e-243 other
291 UQCR11 8.042679e-248 0.3843044 0.148 0.747 2.672904e-243 other
292 TMBIM4 3.106105e-247 -0.6122600 0.036 0.517 1.032283e-242 other
293 MDM4 3.735914e-247 -1.0143773 0.027 0.500 1.241594e-242 other
294 PIK3R1 1.324894e-246 -1.4993774 0.027 0.501 4.403151e-242 other
295 ATP5MJ 2.291164e-246 0.2640736 0.130 0.708 7.614456e-242 other
296 MYCBP2 1.282493e-245 -0.5980924 0.033 0.511 4.262237e-241 other
297 H1-10 8.203591e-245 -0.4533740 0.091 0.622 2.726382e-240 other
298 PRPF38B 1.998165e-244 -0.6949897 0.035 0.512 6.640703e-240 other
299 SNRPF 3.193195e-243 -0.6730889 0.025 0.492 1.061226e-238 other
300 HSP90B1 6.717080e-243 0.3185622 0.089 0.619 2.232354e-238 other
301 BTG2 1.226933e-242 -1.0433362 0.030 0.502 4.077588e-238 other
302 TNRC6B 2.405828e-242 -1.2425277 0.022 0.486 7.995530e-238 other
303 GCC2 5.749835e-242 -1.1180547 0.024 0.489 1.910900e-237 other
304 FAM107B 6.998628e-242 -0.6608858 0.034 0.509 2.325924e-237 other
305 AKNA 1.432179e-241 -1.0183162 0.029 0.498 4.759703e-237 other
306 SNHG8 3.992446e-241 -1.4881179 0.020 0.480 1.326849e-236 other
307 PABPC1 9.217604e-241 -0.5164999 0.221 0.888 3.063378e-236 other
308 RPL18A 3.134618e-240 -0.9654190 0.395 0.933 1.041759e-235 rb
309 PFDN5 4.190251e-240 -0.5786232 0.226 0.907 1.392588e-235 other
310 RNMT 2.121181e-239 -0.9467753 0.023 0.484 7.049533e-235 other
311 RBIS 2.208601e-239 -1.0131724 0.023 0.484 7.340063e-235 other
312 PRPF40A 3.329413e-239 -0.4318486 0.036 0.507 1.106497e-234 other
313 GYPC 5.863404e-239 -0.5895859 0.041 0.518 1.948644e-234 other
314 TMBIM6 9.030863e-239 0.3815942 0.155 0.752 3.001317e-234 other
315 RPL24 1.476697e-238 -0.9270801 0.264 0.922 4.907656e-234 rb
316 DPP7 2.698223e-238 -0.4523929 0.036 0.508 8.967276e-234 other
317 SRSF10 5.977329e-238 -0.3233446 0.043 0.520 1.986505e-233 other
318 SSBP1 6.082253e-238 -0.3824801 0.033 0.501 2.021376e-233 other
319 RNF166 7.664536e-238 -0.7245512 0.029 0.492 2.547232e-233 other
320 PLAC8 8.364834e-237 -0.3268967 0.072 0.577 2.779969e-232 other
321 SRSF3 1.454736e-236 0.4312275 0.120 0.675 4.834669e-232 other
322 COX5A 5.740009e-236 0.3000999 0.074 0.579 1.907634e-231 other
323 GPBP1 1.154266e-235 -0.2662195 0.046 0.524 3.836086e-231 other
324 C12orf57 2.720079e-235 -0.7135353 0.044 0.518 9.039909e-231 other
325 SNRPB2 3.394551e-235 -0.5148932 0.031 0.493 1.128145e-230 other
326 SMIM26 4.899268e-235 -0.9491779 0.022 0.475 1.628223e-230 other
327 KHDRBS1 7.036777e-235 -0.4248875 0.032 0.496 2.338603e-230 other
328 YPEL3 7.522089e-235 0.3802310 0.089 0.609 2.499891e-230 other
329 NDUFB9 1.316700e-234 0.2922268 0.071 0.572 4.375920e-230 other
330 KTN1 1.700787e-234 -0.5554084 0.032 0.494 5.652396e-230 other
331 PPP1R2 1.222271e-233 -0.5211415 0.035 0.499 4.062097e-229 other
332 ID2 2.336094e-233 -0.4734402 0.079 0.585 7.763774e-229 other
333 IFI27 3.080149e-233 3.2951506 0.337 0.102 1.023657e-228 other
334 WDR83OS 2.149355e-231 0.4598540 0.096 0.618 7.143168e-227 other
335 IDS 3.464227e-231 -0.5973385 0.036 0.497 1.151301e-226 other
336 HLA-DQB1 6.693716e-231 -1.4434445 0.042 0.510 2.224590e-226 other
337 ELF1 1.416591e-230 0.5861591 0.089 0.604 4.707897e-226 other
338 SELENOF 2.791561e-230 -0.5132003 0.030 0.486 9.277474e-226 other
339 SBDS 6.551923e-230 -1.3648048 0.021 0.468 2.177466e-225 other
340 UTRN 6.975525e-230 -1.2825737 0.020 0.464 2.318246e-225 other
341 FOXN3 1.301822e-229 -0.5942898 0.031 0.486 4.326474e-225 other
342 PRPF4B 3.137039e-229 -0.7335954 0.029 0.482 1.042563e-224 other
343 SH3KBP1 1.146786e-228 -0.4207626 0.034 0.490 3.811230e-224 other
344 LEPROTL1 1.623279e-228 -0.9377382 0.032 0.488 5.394806e-224 other
345 PAXX 4.665856e-228 -1.2718024 0.020 0.464 1.550650e-223 other
346 CSK 1.670132e-227 -0.5073329 0.036 0.494 5.550518e-223 other
347 SSBP4 8.333488e-227 -0.9784009 0.020 0.462 2.769551e-222 other
348 COPE 2.318760e-226 0.3915486 0.084 0.588 7.706168e-222 other
349 DNAJA1 4.206689e-226 -0.3101899 0.043 0.505 1.398051e-221 other
350 SNRPD3 5.325704e-226 -0.6500324 0.027 0.473 1.769944e-221 other
351 VPS13C 7.853474e-226 -1.3459808 0.016 0.453 2.610023e-221 other
352 METTL9 2.967235e-225 -0.4217209 0.048 0.512 9.861309e-221 other
353 RPS4X 1.146698e-224 -0.8803091 0.395 0.935 3.810936e-220 rb
354 KRTCAP2 1.344531e-224 -0.8654085 0.023 0.465 4.468416e-220 other
355 NUCKS1 3.647243e-224 -0.3607111 0.042 0.502 1.212125e-219 other
356 IL10RA 8.795575e-224 -0.3184868 0.044 0.505 2.923121e-219 other
357 CCDC59 9.799649e-224 -1.2019125 0.018 0.454 3.256815e-219 other
358 KANSL1 1.040120e-223 -0.9253738 0.022 0.461 3.456736e-219 other
359 PEBP1 7.876501e-223 -1.0032572 0.022 0.461 2.617676e-218 other
360 ATRX 8.642617e-223 -1.0645254 0.022 0.461 2.872287e-218 other
361 HSP90AA1 8.756850e-223 0.4570486 0.211 0.853 2.910252e-218 other
362 SNRPD1 2.909754e-222 -0.6675898 0.025 0.465 9.670275e-218 other
363 EIF1AX 3.551388e-222 -0.3436486 0.034 0.483 1.180268e-217 other
364 PKN1 9.418184e-222 -0.3381357 0.035 0.484 3.130039e-217 other
365 ATP6V1F 1.151688e-221 0.3625653 0.093 0.600 3.827521e-217 other
366 HLA-DRB1 6.877510e-221 -0.8840867 0.159 0.702 2.285672e-216 other
367 CTSC 9.890767e-221 -0.7171567 0.041 0.494 3.287097e-216 other
368 HP1BP3 1.816781e-220 -0.5794384 0.028 0.469 6.037891e-216 other
369 RPL7 8.808993e-220 -0.6796909 0.259 0.920 2.927581e-215 rb
370 MBNL1 4.900646e-219 0.5536442 0.119 0.648 1.628681e-214 other
371 MIDN 1.260136e-218 -0.4518170 0.044 0.498 4.187935e-214 other
372 DYNC1H1 1.865969e-218 -0.5124751 0.030 0.471 6.201361e-214 other
373 BPTF 2.296487e-218 -0.7332308 0.030 0.469 7.632144e-214 other
374 ARPC4 3.103911e-218 0.4481075 0.126 0.661 1.031554e-213 other
375 CHD1 8.141690e-218 -0.2660287 0.041 0.490 2.705809e-213 other
376 IL2RG 1.537462e-217 -0.8974722 0.036 0.480 5.109603e-213 other
377 PSMB9 1.707240e-217 0.3521661 0.117 0.643 5.673840e-213 other
378 ATP2B1 1.771700e-217 -0.7167291 0.035 0.479 5.888069e-213 other
379 ARHGAP30 1.852988e-217 -0.3591213 0.039 0.487 6.158221e-213 other
380 PTPN2 1.954515e-217 -0.8652981 0.024 0.458 6.495635e-213 other
381 YWHAZ 3.303771e-217 0.4222483 0.195 0.812 1.097975e-212 other
382 PSMB3 3.378446e-217 0.4319582 0.098 0.605 1.122793e-212 other
383 DOCK8 4.301836e-217 -0.5325548 0.030 0.468 1.429672e-212 other
384 DHX36 1.333201e-216 -1.1120140 0.019 0.446 4.430762e-212 other
385 IK 1.435856e-216 -0.5479367 0.028 0.463 4.771923e-212 other
386 SAMHD1 1.987870e-216 -0.5202482 0.062 0.530 6.606488e-212 other
387 PSMB10 2.791357e-216 -1.3468018 0.017 0.443 9.276794e-212 other
388 RTF1 4.212689e-216 -0.8667711 0.023 0.453 1.400045e-211 other
389 MAGOH 1.054849e-215 -0.4594011 0.027 0.461 3.505685e-211 other
390 PSMB6 1.140941e-215 0.2592743 0.053 0.511 3.791803e-211 other
391 PGAM1 1.518877e-214 0.2750037 0.089 0.582 5.047834e-210 other
392 SEM1 2.698000e-214 -0.4876421 0.031 0.467 8.966535e-210 other
393 ANXA11 3.325674e-214 0.3960987 0.078 0.559 1.105254e-209 other
394 FNBP4 9.797765e-214 -1.1119201 0.016 0.438 3.256189e-209 other
395 ARPC5L 1.246185e-213 -0.4435961 0.035 0.473 4.141571e-209 other
396 RPS17 2.096464e-213 -1.2689758 0.017 0.438 6.967388e-209 rb
397 EML4 8.611448e-213 -0.9699258 0.023 0.450 2.861929e-208 other
398 U2SURP 1.173263e-212 -0.6791733 0.026 0.455 3.899223e-208 other
399 METRNL 1.302649e-212 -0.7864563 0.042 0.485 4.329224e-208 other
400 NDUFA13 5.444116e-212 -0.9674990 0.021 0.444 1.809298e-207 other
401 PRKCB 2.152675e-211 0.5093049 0.117 0.634 7.154200e-207 other
402 EIF4G2 2.523632e-211 0.4488538 0.114 0.630 8.387039e-207 other
403 PHF20 2.719498e-211 -0.9115679 0.022 0.445 9.037979e-207 other
404 HNRNPUL1 3.049371e-211 -0.4385520 0.033 0.466 1.013428e-206 other
405 MYADM 3.297885e-211 -0.6959121 0.047 0.494 1.096019e-206 other
406 P4HB 7.211305e-211 0.4050334 0.086 0.570 2.396605e-206 other
407 PAIP2 1.720426e-210 0.6117768 0.115 0.629 5.717665e-206 other
408 ORMDL1 2.591899e-210 -0.6461050 0.027 0.454 8.613917e-206 other
409 RPL18 5.329346e-210 -0.8608085 0.368 0.932 1.771155e-205 rb
410 CHMP4A 1.563139e-209 -0.5845172 0.027 0.452 5.194937e-205 other
411 UBE2B 2.246783e-209 0.3591922 0.075 0.547 7.466959e-205 other
412 ATP5PB 2.824339e-209 0.3742745 0.071 0.539 9.386407e-205 other
413 CAPZB 2.837594e-209 0.5073473 0.157 0.717 9.430460e-205 other
414 RPL19 2.851089e-209 -0.8016911 0.474 0.942 9.475308e-205 rb
415 MYL12B 3.570964e-209 0.2773069 0.214 0.846 1.186774e-204 other
416 MRPS21 4.118660e-209 -1.0780578 0.016 0.431 1.368796e-204 other
417 PDCD4 6.739636e-209 -0.8753202 0.026 0.450 2.239851e-204 other
418 HMGN3 8.762755e-209 -0.7096460 0.024 0.446 2.912214e-204 other
419 IER5 9.653771e-209 -0.7317349 0.034 0.465 3.208334e-204 other
420 DNAJC8 1.557552e-208 -0.2743928 0.034 0.465 5.176369e-204 other
421 TOMM22 2.584705e-208 -0.4039455 0.028 0.453 8.590010e-204 other
422 CAPNS1 3.016575e-208 0.2674271 0.089 0.574 1.002529e-203 other
423 ACTR3 3.679435e-208 0.3244482 0.089 0.573 1.222824e-203 other
424 PET100 3.812600e-208 -0.3048294 0.037 0.470 1.267079e-203 other
425 LSM3 4.030343e-208 -0.2698388 0.033 0.462 1.339444e-203 other
426 SIVA1 1.021878e-207 -0.4834462 0.026 0.448 3.396110e-203 other
427 MZT2A 1.043607e-207 -1.3420749 0.016 0.430 3.468324e-203 other
428 ATP5F1C 1.720548e-207 0.3737191 0.067 0.529 5.718070e-203 other
429 RACK1 2.091683e-207 -0.7152416 0.285 0.921 6.951498e-203 other
430 EAPP 3.450502e-207 -1.0802730 0.018 0.433 1.146740e-202 other
431 RAD23A 3.888085e-207 -0.7211430 0.024 0.443 1.292166e-202 other
432 ATP5PD 9.044927e-207 0.4521761 0.077 0.548 3.005991e-202 other
433 MICOS10 9.252291e-207 -0.6371664 0.029 0.451 3.074906e-202 other
434 CWC15 1.100065e-206 -0.4214778 0.025 0.445 3.655956e-202 other
435 DHRS7 1.432663e-206 -0.6684089 0.025 0.444 4.761312e-202 other
436 TPR 2.099959e-206 -1.0085801 0.022 0.437 6.979003e-202 other
437 CDC40 2.534628e-206 -0.8113479 0.021 0.436 8.423583e-202 other
438 DDX46 2.601842e-206 -0.2698265 0.036 0.465 8.646962e-202 other
439 TMED10 3.776860e-206 -0.5598514 0.029 0.450 1.255202e-201 other
440 ATM 3.989326e-206 -1.0358642 0.024 0.442 1.325813e-201 other
441 PA2G4 5.900522e-206 -0.6200815 0.026 0.445 1.960979e-201 other
442 HLA-DRA 6.877288e-206 -1.3596632 0.169 0.657 2.285598e-201 other
443 AKAP9 1.472881e-205 -0.3683826 0.034 0.460 4.894974e-201 other
444 PSMB8 1.531712e-205 0.4841606 0.105 0.603 5.090490e-201 other
445 TRAF3IP3 5.499859e-205 -0.8452183 0.026 0.444 1.827823e-200 other
446 NR3C1 1.247876e-204 -0.8133148 0.023 0.439 4.147190e-200 other
447 XRN2 2.514023e-203 -0.4638306 0.029 0.448 8.355105e-199 other
448 SH3BGRL 6.666054e-203 0.6086113 0.139 0.669 2.215396e-198 other
449 GNB1 8.190566e-203 0.2942335 0.068 0.524 2.722053e-198 other
450 GNG5 4.362901e-202 0.3789016 0.131 0.651 1.449966e-197 other
451 STK17A 4.792155e-202 -0.8651662 0.032 0.453 1.592625e-197 other
452 MAPK1IP1L 1.233287e-201 -0.3794706 0.031 0.450 4.098707e-197 other
453 COX14 1.439776e-201 -0.3473432 0.033 0.454 4.784951e-197 other
454 AURKAIP1 1.906658e-201 0.4252050 0.067 0.521 6.336588e-197 other
455 STK10 5.559005e-200 -0.2642682 0.036 0.458 1.847480e-195 other
456 RSF1 6.467096e-200 -0.4756704 0.030 0.447 2.149275e-195 other
457 ATP1A1 1.358678e-199 -0.5843219 0.027 0.439 4.515430e-195 other
458 MRPL20 4.260264e-199 -0.4033352 0.029 0.443 1.415856e-194 other
459 RPS27L 6.098187e-199 0.4333933 0.066 0.515 2.026672e-194 rb
460 WIPF1 6.456424e-199 0.3581139 0.096 0.576 2.145728e-194 other
461 SQSTM1 4.624441e-198 0.6271914 0.133 0.651 1.536887e-193 other
462 KDM2A 5.398447e-198 -0.6355501 0.025 0.433 1.794120e-193 other
463 MRFAP1 5.427810e-198 -0.5855468 0.025 0.434 1.803878e-193 other
464 UBALD2 6.166518e-198 0.6197810 0.114 0.609 2.049380e-193 other
465 PJA2 7.579776e-198 -0.2694627 0.034 0.450 2.519063e-193 other
466 TLE4 2.487176e-197 -0.9821536 0.020 0.423 8.265880e-193 other
467 PYURF 5.857174e-197 -0.4549747 0.026 0.433 1.946573e-192 other
468 BST2 6.033682e-197 0.3035071 0.071 0.522 2.005234e-192 other
469 XBP1 1.005436e-196 -0.4466686 0.033 0.447 3.341465e-192 other
470 ANXA6 1.032937e-196 -0.5267224 0.030 0.442 3.432862e-192 other
471 CD69 1.336817e-196 -2.0018577 0.030 0.440 4.442778e-192 other
472 NEMF 1.971846e-196 -0.8264641 0.023 0.427 6.553232e-192 other
473 GOLGA4 3.050559e-195 -1.2277951 0.016 0.413 1.013823e-190 other
474 NDUFB1 4.212811e-195 -0.3755715 0.035 0.448 1.400085e-190 other
475 ENO1 8.540326e-195 0.4322219 0.166 0.717 2.838292e-190 other
476 MRPL33 1.179824e-194 -1.3525820 0.014 0.406 3.921026e-190 other
477 TAF10 3.524335e-194 0.4722499 0.080 0.536 1.171278e-189 other
478 CDC37 9.457490e-194 0.2957379 0.063 0.503 3.143102e-189 other
479 PRDX5 4.385418e-193 0.5696646 0.102 0.579 1.457450e-188 other
480 UQCRC2 5.786547e-193 -0.8136812 0.019 0.414 1.923101e-188 other
481 PCM1 7.140319e-193 -1.1221814 0.018 0.413 2.373014e-188 other
482 MXD4 1.026270e-192 -1.0512077 0.020 0.416 3.410707e-188 other
483 MYH9 1.543837e-192 0.4928413 0.124 0.623 5.130787e-188 other
484 TRBC2 1.677928e-192 -2.0031629 0.022 0.418 5.576425e-188 other
485 LMAN2 2.816410e-192 -0.2563911 0.031 0.437 9.360056e-188 other
486 YPEL5 3.757524e-192 0.5469471 0.117 0.609 1.248776e-187 other
487 RCSD1 4.115275e-192 -0.9302773 0.019 0.413 1.367671e-187 other
488 GADD45GIP1 1.034628e-191 -0.4358450 0.025 0.423 3.438484e-187 other
489 TSC22D3 1.242128e-191 -0.3569397 0.246 0.846 4.128088e-187 other
490 ZRANB2 5.725990e-191 -1.1433307 0.016 0.406 1.902976e-186 other
491 INPP5D 1.083881e-190 -1.0196710 0.020 0.412 3.602170e-186 other
492 MSN 1.084362e-190 0.3893917 0.162 0.702 3.603767e-186 other
493 DDX18 1.315962e-190 -1.7810735 0.010 0.393 4.373469e-186 other
494 RBM38 1.603995e-190 -0.2997619 0.058 0.487 5.330717e-186 other
495 RPL7A 3.392902e-190 -0.6843246 0.396 0.934 1.127597e-185 rb
496 SELENOT 5.442033e-190 0.3895588 0.066 0.502 1.808605e-185 other
497 SSB 9.188539e-190 -0.2903914 0.033 0.437 3.053719e-185 other
498 BRK1 1.649099e-189 0.6261391 0.139 0.650 5.480617e-185 other
499 CH17-189H20.1 1.899817e-189 -0.4707302 0.030 0.430 6.313853e-185 other
500 ARL6IP5 2.312036e-189 0.6782860 0.143 0.659 7.683819e-185 other
501 NOP10 2.798594e-189 0.3670035 0.085 0.539 9.300847e-185 other
502 ISCU 3.438365e-189 0.5423171 0.093 0.555 1.142706e-184 other
503 CFLAR 3.603723e-189 0.7247017 0.120 0.612 1.197661e-184 other
504 SRP19 3.813448e-189 -0.6439283 0.020 0.412 1.267361e-184 other
505 VDAC2 5.366446e-189 0.4841458 0.068 0.506 1.783485e-184 other
506 STUB1 7.646034e-189 0.2717149 0.048 0.465 2.541083e-184 other
507 STAT3 1.840971e-188 0.3662435 0.065 0.498 6.118283e-184 other
508 RAP1A 1.910330e-188 0.5822601 0.076 0.521 6.348789e-184 other
509 MPHOSPH8 1.950198e-188 -0.8032646 0.024 0.418 6.481287e-184 other
510 GDI2 2.245695e-188 0.3448092 0.066 0.500 7.463344e-184 other
511 GIMAP7 2.619158e-188 -1.1648693 0.023 0.415 8.704509e-184 other
512 PSMA7 4.086098e-188 0.6984510 0.169 0.715 1.357974e-183 other
513 PIK3IP1 4.676799e-188 -1.5506864 0.017 0.404 1.554287e-183 other
514 GNG2 8.485252e-188 -1.1619138 0.016 0.401 2.819989e-183 other
515 TMED2 1.207171e-187 -0.4507442 0.026 0.421 4.011912e-183 other
516 JUN 2.124567e-187 -0.8552578 0.070 0.500 7.060787e-183 other
517 H2AZ1 4.459141e-187 0.8851073 0.127 0.622 1.481951e-182 other
518 HSPA9 5.325499e-187 -0.5312446 0.025 0.417 1.769876e-182 other
519 CDK13 5.534901e-187 -0.9780389 0.020 0.407 1.839469e-182 other
520 YTHDC1 7.478726e-187 -0.3586582 0.032 0.431 2.485480e-182 other
521 RABAC1 7.479340e-187 0.8121176 0.112 0.591 2.485684e-182 other
522 PPP4C 7.768986e-187 0.3099933 0.055 0.475 2.581945e-182 other
523 ATRAID 9.354113e-187 -0.7934966 0.019 0.406 3.108746e-182 other
524 HLA-DMA 1.536131e-186 -1.0107900 0.032 0.430 5.105179e-182 other
525 ANP32A 1.656600e-186 0.5277018 0.066 0.498 5.505544e-182 other
526 RAB7A 1.846635e-186 0.3849975 0.061 0.487 6.137107e-182 other
527 APH1A 2.074051e-186 -0.4380841 0.025 0.418 6.892901e-182 other
528 NDUFB4 2.574125e-186 0.7975490 0.098 0.562 8.554846e-182 other
529 TMEM123 4.000599e-186 0.3087731 0.070 0.505 1.329559e-181 other
530 CD47 1.016135e-185 0.4924254 0.080 0.524 3.377024e-181 other
531 LAMP1 1.503011e-185 0.3785660 0.065 0.494 4.995106e-181 other
532 TMEM230 1.709536e-185 -0.4561471 0.027 0.420 5.681471e-181 other
533 CTNNB1 2.542844e-185 -0.6222189 0.028 0.421 8.450888e-181 other
534 CLTA 2.968416e-185 0.3779174 0.064 0.492 9.865233e-181 other
535 CBX3 3.398877e-185 0.5035484 0.064 0.492 1.129583e-180 other
536 ARHGAP45 7.282537e-185 0.5125598 0.065 0.492 2.420278e-180 other
537 TXNL4A 7.453964e-185 0.4127191 0.057 0.477 2.477250e-180 other
538 GRB2 2.802551e-184 0.5439384 0.107 0.577 9.313998e-180 other
539 CD55 3.185996e-184 0.3426422 0.074 0.511 1.058834e-179 other
540 LENG8 1.632270e-183 0.2902742 0.052 0.466 5.424685e-179 other
541 APBB1IP 3.303830e-183 -0.4709676 0.027 0.416 1.097995e-178 other
542 UBE2L3 7.359819e-183 0.7373497 0.096 0.553 2.445962e-178 other
543 RNF126 8.285303e-183 -1.3536595 0.013 0.389 2.753538e-178 other
544 FXR1 2.873436e-182 -0.7474301 0.021 0.403 9.549576e-178 other
545 SNX2 3.598669e-182 -0.2809955 0.034 0.428 1.195982e-177 other
546 ITGAL 5.843020e-182 -0.7712027 0.023 0.408 1.941869e-177 other
547 CIAO2B 6.000708e-182 0.2849367 0.046 0.452 1.994275e-177 other
548 TPI1 8.235235e-182 0.6490918 0.147 0.657 2.736898e-177 other
549 SMG1 9.550067e-182 -0.3370968 0.027 0.415 3.173869e-177 other
550 RPL29 9.797707e-182 -0.7368864 0.391 0.933 3.256170e-177 rb
551 TRA2A 1.357518e-181 -0.3080822 0.032 0.423 4.511575e-177 other
552 SDCBP 2.487057e-181 0.3727551 0.100 0.559 8.265486e-177 other
553 RNH1 5.740435e-181 0.3635770 0.073 0.503 1.907776e-176 other
554 TMEM243 8.340066e-181 -1.1741046 0.013 0.386 2.771737e-176 other
555 CMTM6 9.664424e-181 0.3086581 0.079 0.514 3.211875e-176 other
556 IDI1 1.376808e-180 -0.4470936 0.028 0.414 4.575684e-176 other
557 MIER1 4.117199e-180 -0.3290780 0.029 0.415 1.368310e-175 other
558 ACAP2 4.600092e-180 -0.2672886 0.035 0.427 1.528794e-175 other
559 SIGIRR 1.587375e-179 -0.4786209 0.026 0.409 5.275483e-175 other
560 OSTF1 2.881626e-179 0.3541204 0.063 0.481 9.576797e-175 other
561 SP110 5.332153e-179 0.2807357 0.052 0.459 1.772088e-174 other
562 POU2F2 7.991335e-179 -1.2625750 0.024 0.404 2.655840e-174 other
563 CNOT1 1.157732e-178 -0.9857158 0.017 0.390 3.847606e-174 other
564 SNHG7 2.166403e-178 -0.3774663 0.034 0.424 7.199825e-174 other
565 TBC1D10C 2.270068e-178 -0.9208962 0.020 0.396 7.544345e-174 other
566 RGS19 2.420485e-178 -0.5144187 0.025 0.406 8.044239e-174 other
567 USF2 3.190357e-178 0.4047208 0.066 0.485 1.060283e-173 other
568 BSG 5.133184e-178 0.3597478 0.081 0.513 1.705962e-173 other
569 KMT2A 1.649403e-177 -1.3172949 0.015 0.385 5.481627e-173 other
570 PRDM2 1.783278e-177 -0.8534441 0.022 0.397 5.926547e-173 other
571 RALY 7.895055e-177 0.2529745 0.049 0.451 2.623843e-172 other
572 RTN4 1.204157e-176 0.4310644 0.091 0.533 4.001897e-172 other
573 MGAT4A 1.374119e-176 -1.5139799 0.014 0.381 4.566748e-172 other
574 VPS51 2.598541e-176 -0.8933510 0.016 0.386 8.635990e-172 other
575 PHIP 4.533831e-176 -0.2612158 0.034 0.420 1.506773e-171 other
576 IFITM1 6.233108e-176 -0.3831787 0.048 0.446 2.071511e-171 other
577 UBA52 7.778659e-176 -0.7274783 0.349 0.948 2.585159e-171 other
578 VPS28 1.222341e-175 0.8368680 0.114 0.578 4.062329e-171 other
579 GMFG 1.634689e-175 0.4363073 0.226 0.823 5.432724e-171 other
580 CNOT6L 2.742908e-175 -0.9675756 0.022 0.395 9.115780e-171 other
581 NONO 4.347326e-175 -0.3026506 0.029 0.407 1.444790e-170 other
582 FTH1 4.851643e-175 1.2130332 0.902 0.993 1.612395e-170 other
583 ZFP36L1 4.925486e-175 0.3058510 0.080 0.508 1.636936e-170 other
584 ITGA4 6.728327e-175 -1.2754466 0.013 0.376 2.236092e-170 other
585 SYNE2 9.464381e-175 -1.9199982 0.018 0.386 3.145393e-170 other
586 CHCHD10 1.118808e-174 -0.3262893 0.030 0.410 3.718248e-170 other
587 CKLF 1.246354e-174 -0.2611954 0.034 0.418 4.142132e-170 other
588 CCT4 1.950563e-174 -0.3447469 0.024 0.398 6.482501e-170 other
589 CHMP2A 2.745075e-174 0.4503875 0.069 0.486 9.122982e-170 other
590 GLTP 3.440944e-174 -0.4467037 0.025 0.400 1.143563e-169 other
591 RBMS1 1.193827e-173 -0.4682144 0.027 0.403 3.967565e-169 other
592 MICOS13 2.909469e-173 -0.6204068 0.019 0.386 9.669330e-169 other
593 NCBP2AS2 3.142067e-173 -0.7027230 0.017 0.383 1.044235e-168 other
594 EMB 3.657437e-173 -0.4862761 0.025 0.398 1.215513e-168 other
595 TMF1 4.059998e-173 -1.0783738 0.015 0.379 1.349300e-168 other
596 NDUFC1 1.194677e-172 -0.2891374 0.027 0.402 3.970389e-168 other
597 VASP 2.085583e-172 0.2652386 0.091 0.527 6.931227e-168 other
598 ITSN2 5.757560e-172 -0.3707766 0.028 0.401 1.913467e-167 other
599 ZNF292 6.030804e-172 -0.3314414 0.031 0.407 2.004277e-167 other
600 DNTTIP2 7.447086e-172 -0.5934436 0.019 0.384 2.474965e-167 other
601 GP9 1.073444e-171 2.7316684 0.264 0.078 3.567485e-167 other
602 DUSP2 2.978583e-171 -1.2960099 0.039 0.421 9.899022e-167 other
603 DOCK2 4.485050e-171 -0.5220592 0.025 0.395 1.490561e-166 other
604 CARD16 6.047028e-171 0.3409301 0.085 0.512 2.009669e-166 other
605 B4GALT1 8.194982e-171 -0.7908291 0.021 0.386 2.723520e-166 other
606 MRPL57 1.149077e-170 -0.4362247 0.023 0.391 3.818842e-166 other
607 PSMA4 1.402252e-170 0.4750403 0.062 0.466 4.660245e-166 other
608 ROMO1 2.453715e-170 -0.3533317 0.023 0.391 8.154675e-166 other
609 ANKRD13D 2.939364e-170 -0.4088170 0.027 0.398 9.768682e-166 other
610 BLOC1S2 3.787118e-170 -0.3823453 0.026 0.395 1.258611e-165 other
611 ADD3 4.965296e-170 0.4333618 0.068 0.478 1.650167e-165 other
612 ATG12 5.651819e-170 -0.4083510 0.025 0.393 1.878326e-165 other
613 FKBP8 6.004727e-170 0.9057609 0.139 0.620 1.995611e-165 other
614 LLPH 8.932803e-170 -1.3213923 0.011 0.366 2.968728e-165 other
615 TTC3 1.052656e-169 -1.0421262 0.017 0.377 3.498397e-165 other
616 PUF60 1.127759e-169 -0.4703466 0.020 0.382 3.747993e-165 other
617 HNRNPL 1.177934e-169 -0.8203466 0.019 0.381 3.914747e-165 other
618 XIST 1.461659e-169 -0.9439520 0.035 0.412 4.857676e-165 other
619 ZNHIT1 3.177964e-169 0.3027430 0.048 0.436 1.056165e-164 other
620 ANAPC11 3.357182e-169 0.3191871 0.049 0.440 1.115726e-164 other
621 AIMP1 3.806851e-169 -0.7045897 0.019 0.380 1.265169e-164 other
622 CD3E 7.777950e-169 -2.1997500 0.021 0.383 2.584924e-164 other
623 NDUFS7 1.504759e-168 0.4128240 0.047 0.433 5.000917e-164 other
624 RESF1 1.715887e-168 -0.2688566 0.032 0.405 5.702580e-164 other
625 DBNL 2.347942e-168 0.4150365 0.065 0.469 7.803150e-164 other
626 DNAJB14 6.017521e-168 -0.7803285 0.020 0.379 1.999863e-163 other
627 RPS19BP1 7.589337e-168 0.4935375 0.062 0.463 2.522240e-163 rb
628 GZMM 9.664537e-168 -2.1188792 0.017 0.374 3.211912e-163 other
629 PSMA2 2.076471e-167 -1.0155606 0.016 0.371 6.900944e-163 other
630 GPATCH8 2.910159e-167 -0.6864381 0.020 0.378 9.671624e-163 other
631 TMC6 3.108179e-167 -0.5726675 0.024 0.387 1.032972e-162 other
632 RB1CC1 4.871899e-167 -0.2759159 0.024 0.387 1.619127e-162 other
633 BNIP2 5.281001e-167 0.4188957 0.064 0.465 1.755088e-162 other
634 EIF2S2 7.134708e-167 0.3049367 0.048 0.433 2.371149e-162 other
635 ETS1 8.535062e-167 -1.8562094 0.014 0.366 2.836543e-162 other
636 GLG1 1.392252e-166 -0.4008403 0.023 0.384 4.627009e-162 other
637 TAF7 2.599821e-166 -0.6723203 0.026 0.389 8.640245e-162 other
638 RHOA 2.882631e-166 0.4518764 0.225 0.807 9.580137e-162 other
639 BCL7C 5.165322e-166 -0.9244095 0.016 0.370 1.716643e-161 other
640 IL32 6.103021e-166 -1.7839274 0.063 0.448 2.028278e-161 other
641 HECTD1 6.656983e-166 -0.7645711 0.016 0.370 2.212382e-161 other
642 ASH1L 7.251661e-166 -1.1388579 0.016 0.370 2.410017e-161 other
643 C1D 1.146246e-165 -0.7334203 0.020 0.376 3.809435e-161 other
644 DNAJB6 1.628198e-165 0.8251132 0.142 0.620 5.411153e-161 other
645 PPHLN1 1.979036e-165 -0.5590201 0.022 0.379 6.577128e-161 other
646 SEPTIN6 2.576128e-165 0.3883025 0.068 0.470 8.561502e-161 other
647 RPL8 4.431470e-165 -0.6523636 0.373 0.934 1.472755e-160 rb
648 WBP11 8.052486e-165 -0.8637661 0.016 0.368 2.676163e-160 other
649 PHF3 9.715267e-165 -0.4650899 0.027 0.388 3.228772e-160 other
650 PRDX1 2.128086e-164 0.6176348 0.067 0.466 7.072480e-160 other
651 YME1L1 5.335746e-164 -0.5551307 0.022 0.377 1.773282e-159 other
652 TTC14 5.602624e-164 -1.6317026 0.011 0.357 1.861976e-159 other
653 AIP 1.047840e-163 -0.5632593 0.019 0.372 3.482393e-159 other
654 MOB1A 1.285481e-163 0.7852706 0.116 0.564 4.272167e-159 other
655 MYDGF 1.885174e-163 0.5285923 0.051 0.434 6.265187e-159 other
656 RBM5 2.504655e-163 0.2734241 0.041 0.414 8.323969e-159 other
657 EPB41L4A-AS1 2.702240e-163 -0.9533326 0.016 0.366 8.980626e-159 other
658 PPP1R18 3.120644e-163 0.5370474 0.082 0.495 1.037115e-158 other
659 SNHG32 4.963495e-163 -0.6776563 0.020 0.373 1.649568e-158 other
660 HLA-DRB5 8.080735e-163 -2.0917372 0.024 0.379 2.685551e-158 other
661 VAPA 8.797971e-163 0.9695664 0.150 0.634 2.923918e-158 other
662 MTCH1 9.268897e-163 0.4203804 0.051 0.434 3.080425e-158 other
663 SORL1 1.812420e-162 0.4311155 0.054 0.438 6.023398e-158 other
664 COX17 3.494499e-162 -0.2945676 0.029 0.389 1.161362e-157 other
665 BCAP31 4.345268e-162 0.6664845 0.078 0.485 1.444106e-157 other
666 BHLHE40 7.428875e-162 -1.3311665 0.016 0.364 2.468912e-157 other
667 UBE2L6 8.724898e-162 0.3137331 0.056 0.442 2.899633e-157 other
668 EIF2A 1.334512e-161 -1.4967388 0.009 0.349 4.435117e-157 other
669 SH3GLB1 1.484011e-161 0.5822958 0.060 0.449 4.931962e-157 other
670 ERGIC3 2.435641e-161 -0.9032272 0.015 0.361 8.094611e-157 other
671 ARF1 3.437600e-161 0.8761670 0.213 0.768 1.142452e-156 other
672 CNOT2 4.559165e-161 -0.7591651 0.019 0.368 1.515193e-156 other
673 CLEC2D 4.688477e-161 -1.2125798 0.020 0.369 1.558168e-156 other
674 CD247 4.736083e-161 -1.7140522 0.020 0.370 1.573990e-156 other
675 NACA 6.576922e-161 -0.6271088 0.335 0.931 2.185774e-156 other
676 TERF2IP 8.599613e-161 0.7798523 0.098 0.524 2.857995e-156 other
677 CASP8 9.396470e-161 -0.7758836 0.020 0.370 3.122823e-156 other
678 BAZ2A 1.620040e-160 0.4000158 0.048 0.424 5.384041e-156 other
679 TMEM165 2.465893e-160 -0.3001618 0.026 0.380 8.195149e-156 other
680 GTF2A2 3.109741e-160 0.6986116 0.067 0.460 1.033491e-155 other
681 USP8 8.524817e-160 -0.6886547 0.020 0.368 2.833138e-155 other
682 OXA1L 1.037485e-159 -0.4229811 0.023 0.374 3.447978e-155 other
683 SUMO3 1.544990e-159 0.5831552 0.067 0.459 5.134620e-155 other
684 PPP1R15A 6.816718e-159 0.4685647 0.106 0.535 2.265468e-154 other
685 ATP6V0E1 7.218764e-159 0.7877514 0.181 0.694 2.399084e-154 other
686 ZC3HAV1 9.981211e-159 -0.5518781 0.022 0.369 3.317156e-154 other
687 PSMD4 1.315445e-158 0.2688283 0.037 0.399 4.371750e-154 other
688 BRD7 2.029170e-158 -0.4640767 0.023 0.371 6.743742e-154 other
689 LTB 2.278126e-158 -2.2138268 0.023 0.370 7.571123e-154 other
690 CCT3 2.624823e-158 -0.2603382 0.024 0.374 8.723335e-154 other
691 TMSB10 4.714735e-158 -0.6416826 0.545 0.946 1.566895e-153 other
692 CAMLG 5.261455e-158 -0.3817563 0.022 0.368 1.748592e-153 other
693 ADD1 1.208578e-157 -0.5295329 0.023 0.371 4.016588e-153 other
694 EIF5B 2.336857e-157 -0.6704025 0.020 0.364 7.766311e-153 other
695 STT3B 2.455380e-157 -0.3987499 0.023 0.370 8.160211e-153 other
696 SIPA1 2.667387e-157 -1.0216295 0.014 0.352 8.864793e-153 other
697 HMGB2 2.926992e-157 0.8011861 0.123 0.568 9.727565e-153 other
698 HLA-DQA1 4.106661e-157 -1.9872945 0.017 0.358 1.364808e-152 other
699 SASH3 5.062312e-157 -0.4106404 0.022 0.368 1.682409e-152 other
700 EPS15 6.048885e-157 -0.8100302 0.017 0.357 2.010286e-152 other
701 MAP1LC3B 1.256999e-156 0.9373400 0.134 0.589 4.177510e-152 other
702 SSNA1 1.899944e-156 0.2686559 0.040 0.401 6.314273e-152 other
703 TPM3 2.171434e-156 0.4393376 0.240 0.824 7.216543e-152 other
704 TXN 2.316991e-156 0.8314398 0.124 0.569 7.700289e-152 other
705 SSR4 1.089038e-155 0.8666309 0.223 0.781 3.619310e-151 other
706 STRAP 1.123489e-155 0.3779335 0.055 0.429 3.733803e-151 other
707 HLA-DMB 1.977203e-155 -1.0937989 0.020 0.360 6.571038e-151 other
708 FBL 3.933599e-155 -0.5121649 0.020 0.359 1.307292e-150 other
709 BBX 4.243032e-155 -0.6139006 0.023 0.366 1.410129e-150 other
710 ZNF394 4.551191e-155 -0.3337811 0.025 0.369 1.512543e-150 other
711 HELZ 7.147535e-155 -0.4720569 0.026 0.371 2.375412e-150 other
712 DDOST 8.455469e-155 -0.4349333 0.021 0.361 2.810091e-150 other
713 BUB3 8.503344e-155 -0.6554344 0.018 0.357 2.826001e-150 other
714 COX19 8.652617e-155 -0.3210549 0.023 0.366 2.875611e-150 other
715 ADPGK 1.011387e-154 -0.3470572 0.023 0.367 3.361244e-150 other
716 NDUFAF8 1.013341e-154 -1.0443245 0.013 0.346 3.367736e-150 other
717 DIAPH1 1.223465e-154 0.4651222 0.066 0.449 4.066065e-150 other
718 BIRC6 1.356580e-154 -0.8668295 0.017 0.354 4.508459e-150 other
719 SEPTIN2 1.521039e-154 0.4551088 0.056 0.430 5.055022e-150 other
720 CD7 2.230574e-154 -1.1957079 0.026 0.371 7.413090e-150 other
721 SNX3 2.416475e-154 0.8988307 0.164 0.648 8.030914e-150 other
722 CST7 2.776702e-154 -1.6751771 0.050 0.412 9.228092e-150 other
723 SELPLG 3.660083e-154 -0.8685049 0.016 0.351 1.216392e-149 other
724 UBE2R2 4.017537e-154 0.4704554 0.058 0.434 1.335188e-149 other
725 KRR1 4.290585e-154 -0.8951729 0.016 0.350 1.425933e-149 other
726 TAGAP 4.454429e-154 -0.6861392 0.024 0.367 1.480385e-149 other
727 PSMB4 8.232642e-154 0.5174870 0.044 0.406 2.736036e-149 other
728 NFKBIA 2.618726e-153 0.3411361 0.253 0.801 8.703073e-149 other
729 RBM23 2.786037e-153 -0.5970044 0.019 0.355 9.259114e-149 other
730 RORA 4.887571e-153 -1.5815143 0.015 0.348 1.624335e-148 other
731 CCZ1 5.004009e-153 -1.2237358 0.012 0.342 1.663032e-148 other
732 ARHGAP9 5.984137e-153 -0.9878414 0.016 0.350 1.988768e-148 other
733 TANK 8.386936e-153 0.3492736 0.036 0.389 2.787314e-148 other
734 RBBP4 2.150491e-152 -0.3006790 0.025 0.366 7.146943e-148 other
735 PPP4R3A 3.299485e-152 -0.5074123 0.022 0.360 1.096551e-147 other
736 SHISA5 3.398025e-152 0.2640110 0.039 0.392 1.129299e-147 other
737 DAZAP1 4.363743e-152 -0.5473438 0.018 0.353 1.450246e-147 other
738 NDUFS8 4.949280e-152 0.5766712 0.050 0.414 1.644844e-147 other
739 DAD1 7.603562e-152 1.0470915 0.115 0.543 2.526968e-147 other
740 LSM5 2.031672e-151 -1.0797440 0.011 0.338 6.752058e-147 other
741 SS18L2 2.456289e-151 -2.5638444 0.004 0.324 8.163231e-147 other
742 GLRX 2.924589e-151 0.4645018 0.074 0.459 9.719579e-147 other
743 SPN 3.018054e-151 -1.8560886 0.009 0.333 1.003020e-146 other
744 RHOH 3.022084e-151 -2.1994554 0.009 0.333 1.004359e-146 other
745 CAPN2 3.224610e-151 0.6491176 0.077 0.467 1.071667e-146 other
746 PSMA5 6.294197e-151 0.3914659 0.037 0.388 2.091813e-146 other
747 EMC10 6.373672e-151 -0.7437134 0.018 0.351 2.118226e-146 other
748 ADRM1 1.188796e-150 0.3674179 0.041 0.394 3.950845e-146 other
749 SIRT7 1.335833e-150 -0.4075345 0.022 0.357 4.439508e-146 other
750 TUBB 1.883172e-150 0.5776172 0.062 0.434 6.258534e-146 other
751 NDUFS5 1.891218e-150 1.0521810 0.168 0.652 6.285274e-146 other
752 YIPF4 2.083503e-150 -0.4424265 0.021 0.355 6.924315e-146 other
753 PPP1R7 2.257327e-150 -0.4383602 0.020 0.354 7.502002e-146 other
754 SLC3A2 3.593285e-150 0.4812219 0.049 0.410 1.194192e-145 other
755 NFE2L2 7.029536e-150 0.2725298 0.051 0.412 2.336196e-145 other
756 EMC6 1.012658e-149 0.2893510 0.036 0.384 3.365466e-145 other
757 NME3 1.304851e-149 -0.6091408 0.018 0.347 4.336542e-145 other
758 ATF4 2.292389e-149 0.8418699 0.111 0.530 7.618526e-145 other
759 CSNK1G2 4.106455e-149 -0.3715034 0.023 0.358 1.364739e-144 other
760 ANXA2 1.324751e-148 0.4205926 0.122 0.553 4.402676e-144 other
761 RBM33 1.512577e-148 -0.5860868 0.018 0.347 5.026899e-144 other
762 POLR2K 1.910923e-148 -0.5871508 0.018 0.346 6.350763e-144 other
763 MEAF6 3.089599e-148 -0.9712137 0.014 0.338 1.026797e-143 other
764 NHP2 4.521215e-148 -0.6183248 0.016 0.342 1.502581e-143 other
765 CCDC85B 1.039190e-147 0.9616746 0.107 0.519 3.453645e-143 other
766 PHPT1 1.354540e-147 -0.2688377 0.025 0.359 4.501678e-143 other
767 MKNK2 2.827543e-147 -0.3609764 0.024 0.356 9.397057e-143 other
768 PPT1 3.503583e-147 -0.6204656 0.024 0.356 1.164381e-142 other
769 ATF6B 3.729331e-147 -0.5771349 0.018 0.344 1.239406e-142 other
770 RPL15 6.261335e-147 -0.5650758 0.424 0.945 2.080892e-142 rb
771 SYNGR2 6.402146e-147 -0.2694520 0.025 0.358 2.127689e-142 other
772 ARFGAP2 1.012496e-146 -0.5259362 0.020 0.348 3.364928e-142 other
773 CNOT7 1.190313e-146 -0.8385133 0.015 0.337 3.955886e-142 other
774 EIF4E2 2.401411e-146 -0.4082848 0.020 0.347 7.980848e-142 other
775 AP2M1 2.460011e-146 0.9473761 0.124 0.551 8.175602e-142 other
776 MT-ND5 4.125082e-146 -0.2796028 0.320 0.939 1.370930e-141 mt
777 SYAP1 4.592092e-146 -0.3755997 0.026 0.358 1.526136e-141 other
778 METAP2 5.910146e-146 -0.5356949 0.020 0.345 1.964178e-141 other
779 SELENOS 1.061956e-145 -0.5167991 0.019 0.344 3.529303e-141 other
780 GIMAP4 1.176592e-145 -0.3723450 0.027 0.360 3.910286e-141 other
781 CAP1 2.542948e-145 0.6726020 0.193 0.696 8.451234e-141 other
782 C6orf62 3.463976e-145 0.4431306 0.049 0.401 1.151218e-140 other
783 TECR 6.559344e-145 -0.4516908 0.022 0.348 2.179933e-140 other
784 TMED4 1.256577e-144 -0.5239699 0.020 0.343 4.176109e-140 other
785 PTP4A2 2.367733e-144 0.5831724 0.231 0.782 7.868923e-140 other
786 VPS29 3.500897e-144 0.6405948 0.056 0.412 1.163488e-139 other
787 USP34 3.910053e-144 -0.7442901 0.019 0.341 1.299467e-139 other
788 EMC4 3.991429e-144 -1.3319376 0.010 0.322 1.326511e-139 other
789 SSH2 4.142974e-144 0.2971484 0.039 0.381 1.376876e-139 other
790 FRG1 5.019273e-144 -1.1581028 0.011 0.325 1.668105e-139 other
791 C1orf56 5.226601e-144 -1.6212350 0.012 0.327 1.737008e-139 other
792 CCT7 9.757843e-144 -0.4598972 0.018 0.339 3.242922e-139 other
793 TSPAN14 1.006990e-143 -0.3188449 0.025 0.352 3.346630e-139 other
794 RER1 1.150674e-143 0.3408428 0.037 0.376 3.824150e-139 other
795 LCK 1.710438e-143 -1.6647469 0.013 0.329 5.684469e-139 other
796 PRPF8 3.242914e-143 -0.3157652 0.023 0.347 1.077750e-138 other
797 NKG7 4.907353e-143 -1.6599903 0.134 0.487 1.630910e-138 other
798 NFKB1 5.780170e-143 -1.1903423 0.010 0.322 1.920982e-138 other
799 TCIRG1 5.825371e-143 0.5993323 0.065 0.428 1.936004e-138 other
800 CSNK2A1 6.189242e-143 -1.1803057 0.012 0.326 2.056933e-138 other
801 UFM1 1.078852e-142 -0.4657847 0.019 0.339 3.585458e-138 other
802 CEMIP2 1.978285e-142 -1.3630580 0.015 0.329 6.574633e-138 other
803 BIRC3 2.147413e-142 -0.7003282 0.022 0.343 7.136713e-138 other
804 IDH2 2.294032e-142 -0.3240120 0.023 0.346 7.623987e-138 other
805 TMCO1 2.994114e-142 -0.4161176 0.020 0.340 9.950637e-138 other
806 QKI 3.382550e-142 0.4697062 0.058 0.414 1.124157e-137 other
807 CCNY 3.423162e-142 0.2528328 0.044 0.386 1.137654e-137 other
808 LTA4H 5.479896e-142 -0.4002955 0.034 0.366 1.821189e-137 other
809 C1orf43 7.374195e-142 0.4835597 0.047 0.392 2.450740e-137 other
810 ARID4A 9.472039e-142 -0.4544906 0.022 0.342 3.147938e-137 other
811 NSD1 1.256311e-141 -0.6326007 0.016 0.332 4.175224e-137 other
812 RNF19A 1.806207e-141 -0.3744279 0.027 0.353 6.002749e-137 other
813 CRBN 2.837978e-141 0.8879197 0.067 0.429 9.431736e-137 other
814 WDR82 3.134777e-141 -0.6754544 0.016 0.330 1.041812e-136 other
815 DGUOK 3.271448e-141 0.4824134 0.043 0.383 1.087233e-136 other
816 EIF1B 4.235973e-141 1.2206048 0.134 0.563 1.407783e-136 other
817 RAB1A 4.653501e-141 0.3037126 0.037 0.372 1.546544e-136 other
818 LNPEP 4.681025e-141 -1.4766430 0.010 0.318 1.555692e-136 other
819 DYNLRB1 4.879681e-141 1.0004242 0.105 0.504 1.621713e-136 other
820 DOK2 6.833671e-141 0.5125225 0.083 0.461 2.271102e-136 other
821 EXOSC6 1.223707e-140 -0.7085253 0.015 0.328 4.066868e-136 other
822 TES 1.268747e-140 -0.5969708 0.018 0.333 4.216554e-136 other
823 APOBEC3G 2.203600e-140 -1.0847900 0.015 0.326 7.323445e-136 other
824 PARK7 3.446622e-140 1.0823357 0.186 0.674 1.145450e-135 other
825 SDF4 8.257974e-140 -0.3171175 0.021 0.338 2.744455e-135 other
826 TMEM167A 9.232862e-140 0.2974706 0.045 0.385 3.068449e-135 other
827 SLC38A1 9.422607e-140 -2.0183752 0.009 0.314 3.131509e-135 other
828 PPP2R1A 1.436149e-139 -0.3915578 0.018 0.333 4.772898e-135 other
829 MAP3K1 1.441204e-139 -0.3965350 0.024 0.344 4.789696e-135 other
830 CTSS 1.451605e-139 -0.5037091 0.231 0.674 4.824265e-135 other
831 SPG21 1.583138e-139 -0.7326228 0.016 0.329 5.261402e-135 other
832 THOC7 1.716472e-139 0.2536765 0.034 0.363 5.704523e-135 other
833 PDCD2 2.531450e-139 -0.6825748 0.014 0.324 8.413020e-135 other
834 HM13 3.413399e-139 0.3303219 0.042 0.378 1.134409e-134 other
835 LARP7 4.049957e-139 -0.3755003 0.021 0.337 1.345963e-134 other
836 USP7 4.887451e-139 -0.3441938 0.022 0.339 1.624295e-134 other
837 PREX1 6.581047e-139 0.4805695 0.042 0.379 2.187145e-134 other
838 CD2 8.649189e-139 -2.5497950 0.008 0.311 2.874471e-134 other
839 NECAP2 9.023849e-139 -0.5764882 0.016 0.328 2.998986e-134 other
840 MAP3K2 1.096278e-138 0.5520241 0.048 0.389 3.643372e-134 other
841 URI1 1.163605e-138 -0.9145495 0.014 0.322 3.867124e-134 other
842 RNF125 1.201462e-138 -1.9628125 0.009 0.312 3.992939e-134 other
843 MAPKAPK2 1.465882e-138 0.3434209 0.045 0.383 4.871712e-134 other
844 RBM6 1.715371e-138 -0.6929985 0.016 0.325 5.700863e-134 other
845 APMAP 2.289251e-138 -1.0798904 0.018 0.330 7.608097e-134 other
846 BCAS2 4.032070e-138 -1.2899417 0.010 0.314 1.340018e-133 other
847 ARHGAP15 4.573402e-138 -2.4999026 0.006 0.305 1.519924e-133 other
848 MAF1 5.200695e-138 0.7093268 0.064 0.419 1.728399e-133 other
849 SLC2A3 7.438302e-138 0.5186709 0.083 0.456 2.472045e-133 other
850 PAFAH1B1 8.386062e-138 0.4245209 0.041 0.373 2.787024e-133 other
851 BNIP3L 1.630423e-137 0.4679991 0.077 0.442 5.418547e-133 other
852 LYAR 1.793899e-137 -1.0456560 0.020 0.333 5.961844e-133 other
853 RPS4Y1 2.133754e-137 -1.4486197 0.027 0.345 7.091317e-133 rb
854 ATP6V0B 2.567513e-137 0.8645944 0.152 0.596 8.532873e-133 other
855 MCRIP1 3.773054e-137 -0.2892467 0.022 0.334 1.253937e-132 other
856 TRIM22 4.201815e-137 0.3072384 0.039 0.369 1.396431e-132 other
857 SYNE1 4.960407e-137 -1.3785823 0.015 0.321 1.648542e-132 other
858 SELL 5.074300e-137 0.5159130 0.082 0.452 1.686393e-132 other
859 PRNP 5.077188e-137 -0.4173040 0.020 0.330 1.687353e-132 other
860 APEX1 5.173010e-137 -0.2967828 0.020 0.331 1.719198e-132 other
861 NPC2 5.569450e-137 0.2729399 0.111 0.509 1.850951e-132 other
862 MPC2 6.776717e-137 0.3960922 0.044 0.379 2.252174e-132 other
863 CLNS1A 6.985079e-137 -0.3337536 0.018 0.327 2.321421e-132 other
864 CD46 7.063966e-137 0.2564607 0.038 0.367 2.347639e-132 other
865 SKAP1 7.491427e-137 -2.1800708 0.008 0.307 2.489701e-132 other
866 LSM6 9.777909e-137 -0.5662279 0.016 0.324 3.249590e-132 other
867 RP11-138A9.1 1.303399e-136 -1.1625804 0.016 0.323 4.331717e-132 other
868 CHD4 1.544834e-136 0.4145998 0.041 0.370 5.134101e-132 other
869 JPT1 1.778065e-136 0.6989467 0.056 0.400 5.909221e-132 other
870 NDFIP1 1.958295e-136 0.7302837 0.068 0.424 6.508196e-132 other
871 GSPT1 2.319831e-136 -1.1847259 0.013 0.316 7.709725e-132 other
872 DNAJB1 2.747878e-136 -0.4988789 0.022 0.335 9.132297e-132 other
873 THUMPD3-AS1 3.957595e-136 -0.3661154 0.024 0.338 1.315267e-131 other
874 ETFB 4.587452e-136 0.4159366 0.037 0.363 1.524594e-131 other
875 PSMF1 5.620739e-136 -0.6030033 0.017 0.324 1.867996e-131 other
876 PPCS 6.901898e-136 -0.3526756 0.021 0.331 2.293777e-131 other
877 COMMD7 7.848381e-136 0.5879867 0.056 0.400 2.608331e-131 other
878 PTPRE 7.997794e-136 0.6622469 0.081 0.449 2.657987e-131 other
879 NFKBIZ 8.209095e-136 0.4398178 0.066 0.418 2.728211e-131 other
880 POLR3GL 8.978348e-136 -0.6121567 0.019 0.328 2.983864e-131 other
881 STAT1 1.210531e-135 0.4148848 0.051 0.389 4.023078e-131 other
882 GABARAPL2 1.369660e-135 1.0488031 0.128 0.542 4.551929e-131 other
883 TSPO 1.883799e-135 0.3519093 0.197 0.686 6.260617e-131 other
884 TAF9 2.446288e-135 -0.6899911 0.015 0.319 8.129995e-131 other
885 GZMA 2.662213e-135 -1.6021941 0.040 0.364 8.847598e-131 other
886 CYFIP2 3.091500e-135 -1.2946826 0.011 0.312 1.027429e-130 other
887 PMF1 3.411742e-135 -0.4949077 0.016 0.321 1.133858e-130 other
888 HDAC1 4.093853e-135 -0.5710409 0.018 0.325 1.360551e-130 other
889 UBE3A 5.318532e-135 -1.3671679 0.010 0.307 1.767561e-130 other
890 PCIF1 9.712403e-135 -0.7395570 0.016 0.320 3.227820e-130 other
891 SLC9A3R1 1.158958e-134 -0.3209905 0.027 0.342 3.851682e-130 other
892 FUBP1 1.574485e-134 -1.1494183 0.011 0.309 5.232644e-130 other
893 PDCD5 1.846433e-134 -0.3463930 0.016 0.321 6.136434e-130 other
894 UPP1 1.968100e-134 0.8079335 0.074 0.432 6.540782e-130 other
895 PABPC4 2.915011e-134 -1.1852221 0.011 0.310 9.687746e-130 other
896 IDH3B 3.532383e-134 -0.4613234 0.018 0.323 1.173952e-129 other
897 SPOCK2 3.852497e-134 -1.8963996 0.010 0.308 1.280339e-129 other
898 TM9SF2 4.064367e-134 -0.3303114 0.021 0.329 1.350752e-129 other
899 PLEKHA2 5.767016e-134 -1.0772108 0.012 0.311 1.916610e-129 other
900 SPSB3 6.261077e-134 -0.6009093 0.018 0.322 2.080806e-129 other
901 CCDC88C 1.359195e-133 -0.4610010 0.024 0.334 4.517147e-129 other
902 NUFIP2 2.031727e-133 -0.3340833 0.020 0.326 6.752240e-129 other
903 SRPK2 2.151108e-133 -0.3760080 0.020 0.326 7.148992e-129 other
904 BDP1 2.171356e-133 -1.4159367 0.010 0.305 7.216284e-129 other
905 SETX 3.249233e-133 -0.5461041 0.020 0.325 1.079850e-128 other
906 PRDX2 3.806896e-133 -0.3899536 0.025 0.334 1.265184e-128 other
907 MMP24OS 4.391989e-133 0.5635300 0.061 0.405 1.459634e-128 other
908 ATF7IP 4.456689e-133 -1.2168025 0.012 0.310 1.481136e-128 other
909 SLIRP 4.729584e-133 -0.6488327 0.013 0.311 1.571830e-128 other
910 THEMIS2 5.387168e-133 0.2904639 0.053 0.389 1.790371e-128 other
911 BIN1 7.389920e-133 -0.8647194 0.015 0.314 2.455966e-128 other
912 RFC1 9.580188e-133 -1.0726360 0.010 0.305 3.183880e-128 other
913 TIAL1 1.001862e-132 -0.3095364 0.021 0.326 3.329590e-128 other
914 ATP6V0D1 1.161869e-132 0.8064689 0.096 0.473 3.861355e-128 other
915 PSMD6 1.249163e-132 0.4148030 0.038 0.359 4.151469e-128 other
916 TNIP1 1.382067e-132 0.4660931 0.042 0.367 4.593162e-128 other
917 SFSWAP 1.567425e-132 -0.8844251 0.011 0.307 5.209181e-128 other
918 RNF115 1.669164e-132 -0.5589251 0.020 0.324 5.547300e-128 other
919 PFDN1 1.700633e-132 -0.3855685 0.016 0.317 5.651885e-128 other
920 VMP1 1.724589e-132 0.3164715 0.056 0.395 5.731498e-128 other
921 C16orf54 1.787236e-132 -1.1745601 0.013 0.310 5.939701e-128 other
922 PUM1 2.420456e-132 -0.4680804 0.017 0.318 8.044144e-128 other
923 RNF149 2.709448e-132 0.8225440 0.067 0.414 9.004579e-128 other
924 MRPL47 3.219566e-132 -0.3701939 0.016 0.316 1.069990e-127 other
925 PSMC3 5.183684e-132 -0.2832365 0.016 0.316 1.722745e-127 other
926 H4C3 7.166031e-132 0.5657433 0.053 0.387 2.381559e-127 other
927 SREK1IP1 8.071490e-132 -0.8995277 0.013 0.309 2.682479e-127 other
928 DHX9 1.127484e-131 -0.5581034 0.016 0.314 3.747082e-127 other
929 ANXA7 1.958431e-131 0.7555568 0.063 0.405 6.508650e-127 other
930 CYTH4 2.201188e-131 0.2737452 0.037 0.355 7.315428e-127 other
931 C16orf72 3.417521e-131 0.4867592 0.042 0.365 1.135779e-126 other
932 TPP1 3.917844e-131 0.3892778 0.051 0.383 1.302056e-126 other
933 TRAPPC1 5.677588e-131 1.0773434 0.160 0.600 1.886890e-126 other
934 GPR65 6.815346e-131 -1.0895034 0.013 0.307 2.265012e-126 other
935 RBM26 1.076071e-130 -1.0370279 0.013 0.306 3.576215e-126 other
936 LAMTOR2 1.515994e-130 0.3867352 0.044 0.368 5.038256e-126 other
937 CENPC 1.785963e-130 -0.7506774 0.016 0.313 5.935469e-126 other
938 NOSIP 1.786558e-130 -0.2513631 0.029 0.339 5.937446e-126 other
939 MRPS34 2.009604e-130 0.3516104 0.034 0.347 6.678719e-126 other
940 ACP1 3.678177e-130 0.8590485 0.067 0.411 1.222405e-125 other
941 DUS1L 3.703187e-130 -0.5221647 0.016 0.312 1.230717e-125 other
942 TRBC1 5.568007e-130 -2.8162706 0.010 0.300 1.850472e-125 other
943 RBL2 8.782727e-130 -0.7926731 0.014 0.308 2.918852e-125 other
944 TRAPPC10 9.224366e-130 -0.6736851 0.016 0.312 3.065626e-125 other
945 CD99 9.741269e-130 0.6100603 0.224 0.737 3.237413e-125 other
946 IREB2 1.224426e-129 -1.0185343 0.013 0.305 4.069258e-125 other
947 RAB8A 1.618221e-129 0.7445319 0.074 0.423 5.377995e-125 other
948 SAFB2 2.360806e-129 -0.6242099 0.016 0.311 7.845901e-125 other
949 PHF11 3.612837e-129 -0.5980867 0.016 0.311 1.200690e-124 other
950 DICER1 3.723645e-129 -0.3120152 0.022 0.321 1.237516e-124 other
951 FAM89B 4.195145e-129 0.4391490 0.048 0.372 1.394215e-124 other
952 TUBB1 5.249448e-129 2.7301797 0.287 0.110 1.744601e-124 other
953 NFATC2IP 5.964141e-129 -0.9186705 0.013 0.305 1.982122e-124 other
954 ADAM10 6.411852e-129 -0.2740441 0.022 0.322 2.130915e-124 other
955 WHAMM 7.118998e-129 -1.0404837 0.015 0.308 2.365928e-124 other
956 NR4A2 7.379760e-129 -1.4946193 0.015 0.308 2.452589e-124 other
957 DNAJC15 7.964236e-129 0.9948314 0.076 0.427 2.646834e-124 other
958 PCGF5 8.764797e-129 0.6410335 0.053 0.381 2.912893e-124 other
959 RPL7L1 8.812370e-129 -0.6657053 0.015 0.309 2.928703e-124 rb
960 CCNK 1.026127e-128 -0.9244116 0.011 0.300 3.410232e-124 other
961 TOP1 1.059438e-128 0.7897019 0.065 0.405 3.520936e-124 other
962 CTSW 1.370861e-128 -1.5681589 0.040 0.354 4.555920e-124 other
963 LPGAT1 1.452586e-128 -0.3038065 0.020 0.318 4.827525e-124 other
964 LCP2 1.883209e-128 0.3229594 0.037 0.351 6.258657e-124 other
965 EPB41 1.916383e-128 0.2760805 0.048 0.371 6.368906e-124 other
966 GLS 1.974714e-128 -0.9739949 0.011 0.299 6.562766e-124 other
967 PYCARD 2.016463e-128 0.5195970 0.107 0.488 6.701512e-124 other
968 ELOVL5 2.416547e-128 -0.5119933 0.016 0.309 8.031152e-124 other
969 ETF1 4.076715e-128 0.5564828 0.039 0.354 1.354856e-123 other
970 AGTRAP 4.781498e-128 0.6291725 0.068 0.410 1.589083e-123 other
971 RP11-138A9.2 5.458038e-128 -3.2295720 0.004 0.285 1.813924e-123 other
972 GNG11 5.697079e-128 2.6741914 0.344 0.154 1.893367e-123 other
973 UHMK1 6.461551e-128 -0.5200816 0.018 0.312 2.147432e-123 other
974 SNRK 6.545409e-128 -0.5239281 0.019 0.314 2.175301e-123 other
975 ERAP2 7.882788e-128 -0.8942456 0.014 0.304 2.619766e-123 other
976 FBXW5 8.730815e-128 0.6638338 0.057 0.388 2.901599e-123 other
977 COPS2 1.175504e-127 -0.4827059 0.016 0.309 3.906669e-123 other
978 COMMD2 1.289975e-127 -1.1841236 0.010 0.295 4.287104e-123 other
979 BIN2 1.725215e-127 0.9767336 0.182 0.640 5.733580e-123 other
980 THUMPD1 2.093246e-127 -0.8171652 0.014 0.303 6.956693e-123 other
981 TUBA1B 2.464072e-127 0.8923442 0.186 0.644 8.189096e-123 other
982 ANAPC5 3.998755e-127 0.6728946 0.059 0.391 1.328946e-122 other
983 METTL26 5.078138e-127 0.4599325 0.032 0.339 1.687668e-122 other
984 ADA2 6.556573e-127 -0.3979303 0.026 0.326 2.179012e-122 other
985 PRF1 7.361330e-127 -1.9775682 0.024 0.321 2.446464e-122 other
986 TRIM56 7.818825e-127 -0.3788500 0.022 0.318 2.598508e-122 other
987 ERBIN 8.687844e-127 0.3976449 0.044 0.362 2.887318e-122 other
988 MKRN1 1.054077e-126 0.7551506 0.077 0.426 3.503118e-122 other
989 NSMCE3 1.206098e-126 -1.2624181 0.012 0.299 4.008348e-122 other
990 SPAG7 1.339238e-126 -0.3982527 0.017 0.309 4.450822e-122 other
991 RTF2 1.587926e-126 0.5492833 0.043 0.359 5.277313e-122 other
992 SERPINB6 1.592579e-126 0.4847636 0.051 0.374 5.292778e-122 other
993 GNPTAB 1.614788e-126 -0.5462137 0.020 0.313 5.366586e-122 other
994 SLC25A36 1.750822e-126 -0.6897145 0.014 0.302 5.818682e-122 other
995 TSC22D4 3.000607e-126 0.5346729 0.048 0.368 9.972216e-122 other
996 PSTPIP1 3.121681e-126 0.3780406 0.036 0.345 1.037459e-121 other
997 MRPL43 3.803198e-126 -0.3779937 0.015 0.304 1.263955e-121 other
998 HOPX 5.017657e-126 -1.7973549 0.016 0.306 1.667568e-121 other
999 SEC11C 6.742472e-126 0.7296685 0.042 0.355 2.240793e-121 other
1000 RAB18 6.785797e-126 -0.4974160 0.016 0.305 2.255192e-121 other
1001 TWF2 6.790949e-126 0.7870452 0.060 0.391 2.256904e-121 other
1002 MAPRE1 7.434656e-126 0.6513002 0.049 0.369 2.470833e-121 other
1003 DNAJC21 9.799484e-126 -0.2973612 0.019 0.310 3.256760e-121 other
1004 IFNGR1 1.084910e-125 0.5456070 0.060 0.390 3.605590e-121 other
1005 SYTL1 1.099522e-125 -0.8483361 0.013 0.299 3.654153e-121 other
1006 EIF2AK2 2.353991e-125 0.3806640 0.041 0.353 7.823253e-121 other
1007 BIRC2 2.430535e-125 -0.6614549 0.016 0.304 8.077638e-121 other
1008 STX10 3.015022e-125 0.4830959 0.038 0.347 1.002012e-120 other
1009 IFITM2 4.285485e-125 0.8160042 0.244 0.770 1.424238e-120 other
1010 MVP 4.885173e-125 0.2738521 0.035 0.340 1.623538e-120 other
1011 BRAF 5.547880e-125 -0.7716873 0.015 0.301 1.843782e-120 other
1012 IMP3 7.169391e-125 -0.9681257 0.011 0.293 2.382675e-120 other
1013 ABT1 8.125846e-125 -1.2866674 0.008 0.288 2.700544e-120 other
1014 CHCHD5 1.323986e-124 -0.6518672 0.015 0.300 4.400135e-120 other
1015 KAT6A 1.481016e-124 -0.3953329 0.021 0.312 4.922008e-120 other
1016 SUPT4H1 1.559670e-124 1.0415759 0.102 0.471 5.183406e-120 other
1017 SMIM7 1.643479e-124 0.3225602 0.039 0.348 5.461938e-120 other
1018 ZFAND6 2.356875e-124 0.6681964 0.055 0.378 7.832839e-120 other
1019 PARP14 2.491229e-124 0.4120827 0.042 0.353 8.279349e-120 other
1020 HEXA 2.563475e-124 -0.2668717 0.020 0.310 8.519452e-120 other
1021 PDLIM2 2.866455e-124 -0.3550945 0.018 0.307 9.526376e-120 other
1022 SLA 3.597015e-124 0.7564900 0.064 0.395 1.195432e-119 other
1023 MTF2 4.817694e-124 -1.5984743 0.008 0.285 1.601112e-119 other
1024 KDELR2 5.175018e-124 0.2795959 0.030 0.330 1.719865e-119 other
1025 DDHD1 7.310728e-124 -0.9166261 0.013 0.295 2.429647e-119 other
1026 RPS6KA3 7.807618e-124 -0.5469408 0.016 0.302 2.594784e-119 rb
1027 NDUFA5 1.167133e-123 0.8454456 0.063 0.392 3.878850e-119 other
1028 TXNDC17 1.310189e-123 0.5068697 0.038 0.344 4.354283e-119 other
1029 TXN2 1.370445e-123 0.2783475 0.029 0.326 4.554536e-119 other
1030 RBM4 1.382236e-123 -1.4752440 0.009 0.287 4.593722e-119 other
1031 CDKN1B 1.475553e-123 -1.5039630 0.008 0.286 4.903852e-119 other
1032 HPS1 1.505090e-123 -0.6290473 0.015 0.299 5.002017e-119 other
1033 TUT4 1.640020e-123 -1.0108259 0.013 0.296 5.450442e-119 other
1034 POLR2B 1.739110e-123 -0.6795979 0.015 0.299 5.779758e-119 other
1035 PARP8 1.890955e-123 -0.3375246 0.023 0.314 6.284398e-119 other
1036 IQGAP2 2.121519e-123 0.8475972 0.089 0.444 7.050655e-119 other
1037 CCNH 2.456127e-123 -0.5481120 0.018 0.305 8.162692e-119 other
1038 SNHG15 2.471749e-123 0.2864532 0.026 0.320 8.214611e-119 other
1039 PTEN 3.847205e-123 0.8837176 0.057 0.380 1.278580e-118 other
1040 CTBP1 6.429982e-123 -0.3579738 0.018 0.303 2.136940e-118 other
1041 CHP1 7.825761e-123 -0.4909178 0.018 0.305 2.600813e-118 other
1042 NOP58 8.130721e-123 -0.6697980 0.015 0.297 2.702164e-118 other
1043 DNM2 8.531980e-123 -0.5190721 0.016 0.301 2.835518e-118 other
1044 MOB3A 8.785034e-123 0.4398818 0.036 0.338 2.919618e-118 other
1045 ATOX1 1.103884e-122 0.3877943 0.044 0.354 3.668648e-118 other
1046 ORAI1 1.324206e-122 0.3840953 0.043 0.352 4.400867e-118 other
1047 REST 1.473412e-122 -0.4329707 0.018 0.303 4.896737e-118 other
1048 SAP30BP 1.512343e-122 -0.3710361 0.016 0.300 5.026119e-118 other
1049 AKIRIN1 3.143405e-122 0.3500026 0.041 0.348 1.044679e-117 other
1050 MDH1 4.119011e-122 0.3236641 0.030 0.325 1.368912e-117 other
1051 CMTM3 4.393752e-122 -0.2873976 0.020 0.306 1.460220e-117 other
1052 TSTD1 5.835866e-122 -0.6438605 0.018 0.302 1.939492e-117 other
1053 IL16 6.044658e-122 -1.0916412 0.011 0.288 2.008882e-117 other
1054 MMADHC 7.010887e-122 -0.6995546 0.013 0.291 2.329998e-117 other
1055 MUC20-OT1 7.320618e-122 -0.9487493 0.011 0.289 2.432934e-117 other
1056 VMA21 1.026824e-121 -0.3997989 0.013 0.293 3.412546e-117 other
1057 OLA1 1.207744e-121 -0.5706406 0.015 0.295 4.013818e-117 other
1058 WDR33 1.287716e-121 -0.3167841 0.020 0.306 4.279596e-117 other
1059 C1orf162 2.098676e-121 0.5870934 0.096 0.453 6.974741e-117 other
1060 THOC2 2.370208e-121 -0.3556454 0.022 0.308 7.877150e-117 other
1061 TRIM44 2.574849e-121 -0.5672500 0.014 0.293 8.557255e-117 other
1062 UPF2 2.701526e-121 -1.0264786 0.010 0.286 8.978253e-117 other
1063 ZNF644 2.950533e-121 -0.7119592 0.014 0.293 9.805801e-117 other
1064 ALOX5AP 4.473181e-121 0.3272110 0.062 0.385 1.486617e-116 other
1065 AP1S2 5.931343e-121 0.2737285 0.084 0.429 1.971223e-116 other
1066 ARL8A 6.142408e-121 0.3456984 0.032 0.327 2.041368e-116 other
1067 SH3BP1 7.209116e-121 -0.4426139 0.015 0.294 2.395878e-116 other
1068 ACRBP 7.982197e-121 2.7168034 0.251 0.090 2.652803e-116 other
1069 AKT1 8.883598e-121 -0.2857671 0.017 0.298 2.952375e-116 other
1070 NAPA 9.800556e-121 0.8375214 0.065 0.391 3.257117e-116 other
1071 IDH3G 1.005932e-120 0.6783198 0.042 0.347 3.343115e-116 other
1072 PRMT1 1.012988e-120 -0.5768766 0.015 0.293 3.366565e-116 other
1073 SMARCB1 1.015776e-120 -0.9477706 0.011 0.286 3.375829e-116 other
1074 RNASEH2B 1.030822e-120 -0.5437841 0.018 0.299 3.425835e-116 other
1075 PCF11 1.113753e-120 -0.5883907 0.016 0.295 3.701446e-116 other
1076 FIBP 1.408424e-120 0.4056627 0.030 0.324 4.680757e-116 other
1077 FDFT1 2.701349e-120 -0.2937803 0.019 0.301 8.977664e-116 other
1078 MARCHF1 3.106693e-120 -0.5848845 0.024 0.311 1.032478e-115 other
1079 BID 3.801483e-120 0.3449014 0.049 0.360 1.263385e-115 other
1080 ZFR 4.235887e-120 -0.9958823 0.011 0.285 1.407755e-115 other
1081 AMD1 4.309461e-120 0.4451087 0.042 0.345 1.432206e-115 other
1082 SMARCA5 4.499202e-120 -0.6970314 0.015 0.293 1.495265e-115 other
1083 PCNP 5.075994e-120 0.9362602 0.076 0.412 1.686956e-115 other
1084 VPS35 6.058277e-120 -0.6056042 0.015 0.293 2.013408e-115 other
1085 LYPLA1 6.118427e-120 0.3805141 0.034 0.329 2.033398e-115 other
1086 STMP1 9.678236e-120 1.1196382 0.109 0.476 3.216465e-115 other
1087 RNASEH2C 1.745995e-119 0.2874391 0.030 0.321 5.802640e-115 other
1088 MLLT6 2.083914e-119 -0.2733744 0.018 0.299 6.925679e-115 other
1089 UFD1 2.121135e-119 0.6901208 0.047 0.354 7.049381e-115 other
1090 MRPL51 2.536603e-119 0.5126178 0.035 0.330 8.430147e-115 other
1091 UBE2J1 2.653767e-119 0.8236769 0.073 0.404 8.819530e-115 other
1092 APOBEC3C 3.945917e-119 -0.6092026 0.016 0.294 1.311386e-114 other
1093 TTC17 4.555721e-119 -0.8171372 0.012 0.286 1.514048e-114 other
1094 PITHD1 4.768234e-119 -0.5791146 0.017 0.295 1.584675e-114 other
1095 CD3D 4.989109e-119 -1.5218219 0.023 0.308 1.658080e-114 other
1096 MRPL11 6.666749e-119 -0.3107636 0.016 0.292 2.215627e-114 other
1097 HIF1A 8.046489e-119 0.9336992 0.082 0.420 2.674170e-114 other
1098 NUP214 1.028092e-118 0.2591618 0.041 0.341 3.416761e-114 other
1099 POLR2F 1.240752e-118 -0.4910127 0.015 0.291 4.123515e-114 other
1100 PIGT 1.462343e-118 -0.5338318 0.013 0.287 4.859952e-114 other
1101 CD83 1.886231e-118 -0.7682874 0.027 0.313 6.268700e-114 other
1102 KDELR1 2.317737e-118 0.4880605 0.034 0.326 7.702769e-114 other
1103 GZMH 2.351284e-118 -2.0363102 0.034 0.323 7.814259e-114 other
1104 HERPUD2 2.570559e-118 -1.6968799 0.008 0.275 8.542996e-114 other
1105 LY6E 2.598897e-118 0.9516570 0.205 0.675 8.637176e-114 other
1106 ADH5 3.311998e-118 -0.6408266 0.014 0.288 1.100710e-113 other
1107 MPC1 3.317850e-118 -0.5509455 0.015 0.289 1.102654e-113 other
1108 COMT 3.633321e-118 0.7711529 0.048 0.353 1.207498e-113 other
1109 DERL2 4.565385e-118 -0.2883170 0.020 0.298 1.517260e-113 other
1110 CYBB 5.640387e-118 -0.4074377 0.065 0.385 1.874526e-113 other
1111 ITGB1 6.296252e-118 0.9090572 0.133 0.521 2.092497e-113 other
1112 VPS37B 1.387485e-117 -0.3741668 0.023 0.304 4.611169e-113 other
1113 UQCRH 1.557365e-117 0.9318744 0.250 0.775 5.175745e-113 other
1114 CLTC 1.857592e-117 0.3668109 0.035 0.327 6.173521e-113 other
1115 HECA 1.920269e-117 -0.3462850 0.019 0.296 6.381823e-113 other
1116 CERT1 2.470723e-117 -0.6389241 0.015 0.287 8.211201e-113 other
1117 WDR26 2.709863e-117 0.4287451 0.037 0.332 9.005958e-113 other
1118 ZNF430 2.734245e-117 -1.2387503 0.010 0.279 9.086991e-113 other
1119 CCDC186 3.032777e-117 -0.4441702 0.016 0.291 1.007913e-112 other
1120 PF4 3.614055e-117 2.6404062 0.399 0.216 1.201095e-112 other
1121 TNFAIP8 5.244135e-117 0.5671136 0.046 0.347 1.742836e-112 other
1122 ITGB1BP1 6.422523e-117 -1.1319519 0.010 0.278 2.134461e-112 other
1123 NXT1 8.699931e-117 -0.4559577 0.016 0.289 2.891335e-112 other
1124 IRAK1 8.970045e-117 -0.3751719 0.017 0.291 2.981105e-112 other
1125 CYBC1 1.027710e-116 -0.2600462 0.020 0.298 3.415493e-112 other
1126 OGFRL1 1.280856e-116 -0.3042121 0.020 0.297 4.256798e-112 other
1127 KXD1 1.670007e-116 -0.4627893 0.016 0.288 5.550100e-112 other
1128 ZNF800 1.691707e-116 -0.7960779 0.012 0.281 5.622218e-112 other
1129 TNFSF12 2.699432e-116 -0.9288609 0.010 0.277 8.971294e-112 other
1130 TSN 2.822110e-116 -0.7878577 0.011 0.279 9.379000e-112 other
1131 RAP2B 3.341469e-116 0.5531107 0.053 0.360 1.110504e-111 other
1132 MARCHF6 3.343727e-116 -0.2624042 0.023 0.303 1.111254e-111 other
1133 MT-CO1 4.051977e-116 -0.4733824 0.866 0.993 1.346634e-111 mt
1134 HMGA1 4.058310e-116 0.3635919 0.034 0.322 1.348739e-111 other
1135 MFF 4.296701e-116 0.3192942 0.032 0.319 1.427966e-111 other
1136 HADHB 4.379840e-116 0.3402835 0.029 0.313 1.455596e-111 other
1137 SIK3 4.447480e-116 -0.8114039 0.012 0.280 1.478076e-111 other
1138 SMC3 5.664416e-116 0.3705233 0.034 0.323 1.882512e-111 other
1139 MED6 5.786055e-116 -1.3243959 0.008 0.273 1.922937e-111 other
1140 PICALM 6.015590e-116 0.3466115 0.036 0.326 1.999221e-111 other
1141 NAAA 7.074271e-116 -0.5554536 0.015 0.285 2.351063e-111 other
1142 CEBPZ 8.241331e-116 -1.5733609 0.007 0.270 2.738924e-111 other
1143 PITPNC1 1.129505e-115 -1.5090823 0.007 0.270 3.753796e-111 other
1144 HNRNPAB 2.012354e-115 -0.2560207 0.018 0.292 6.687858e-111 other
1145 GLRX5 2.129384e-115 0.2532819 0.040 0.333 7.076795e-111 other
1146 LPP 2.224620e-115 -0.3027951 0.019 0.292 7.393301e-111 other
1147 ABCF1 2.763988e-115 -0.5629914 0.015 0.285 9.185838e-111 other
1148 MPG 2.827640e-115 -0.3144071 0.018 0.291 9.397379e-111 other
1149 TMEM87A 3.030860e-115 -0.3806871 0.017 0.288 1.007276e-110 other
1150 EIF3J 3.639690e-115 -0.3704045 0.018 0.290 1.209615e-110 other
1151 GTF3C6 3.924498e-115 1.0761895 0.071 0.393 1.304268e-110 other
1152 IL27RA 4.216147e-115 -1.7932301 0.005 0.265 1.401194e-110 other
1153 ZNHIT3 4.286954e-115 -0.8182845 0.010 0.275 1.424726e-110 other
1154 KCMF1 4.504896e-115 0.5113155 0.041 0.334 1.497157e-110 other
1155 PSMD12 5.449381e-115 -0.4307560 0.016 0.287 1.811047e-110 other
1156 SMARCC1 6.223481e-115 -0.3067300 0.017 0.288 2.068312e-110 other
1157 NUTM2B-AS1 7.565184e-115 -0.6195612 0.016 0.286 2.514213e-110 other
1158 SDHC 7.777304e-115 0.3555278 0.028 0.309 2.584709e-110 other
1159 UQCRC1 8.537332e-115 0.7756740 0.046 0.344 2.837297e-110 other
1160 UBA2 8.581837e-115 -0.5769551 0.013 0.280 2.852088e-110 other
1161 PPP3CA 8.865271e-115 -0.5929442 0.015 0.283 2.946284e-110 other
1162 COPZ1 9.991198e-115 0.3055754 0.032 0.316 3.320475e-110 other
1163 ARID5B 1.042127e-114 -1.8335668 0.009 0.271 3.463405e-110 other
1164 CMC1 1.157151e-114 -1.8320185 0.015 0.283 3.845676e-110 other
1165 BLOC1S6 1.416657e-114 0.4519260 0.042 0.337 4.708119e-110 other
1166 HSBP1 1.426802e-114 0.7393749 0.069 0.388 4.741832e-110 other
1167 RP5-1171I10.5 1.573483e-114 -0.8084871 0.015 0.282 5.229313e-110 other
1168 DDX27 1.657445e-114 -0.4918449 0.015 0.282 5.508352e-110 other
1169 OPTN 1.991966e-114 -0.4184632 0.025 0.302 6.620101e-110 other
1170 DEGS1 2.134976e-114 -0.6906709 0.012 0.277 7.095380e-110 other
1171 TOB1 2.813763e-114 -1.1239339 0.011 0.275 9.351259e-110 other
1172 TIMM8B 2.933342e-114 -0.2578955 0.018 0.289 9.748670e-110 other
1173 NFATC3 3.052132e-114 -0.9118381 0.012 0.277 1.014346e-109 other
1174 SRPRA 3.584111e-114 -0.3524549 0.018 0.289 1.191143e-109 other
1175 PMPCB 3.772260e-114 -0.8357083 0.011 0.274 1.253673e-109 other
1176 KLRD1 3.983033e-114 -2.1388725 0.015 0.283 1.323721e-109 other
1177 NCOA3 4.232337e-114 -0.2606863 0.021 0.294 1.406575e-109 other
1178 ITGB7 6.303485e-114 -1.1767690 0.013 0.278 2.094900e-109 other
1179 FGL2 1.059187e-113 -0.2522442 0.064 0.376 3.520101e-109 other
1180 NDUFA9 1.429317e-113 -0.3853503 0.013 0.277 4.750191e-109 other
1181 TAF15 1.671349e-113 -0.4234239 0.015 0.282 5.554563e-109 other
1182 PFDN4 1.945427e-113 -0.7939701 0.010 0.272 6.465433e-109 other
1183 IRF3 1.947555e-113 -0.3135746 0.018 0.287 6.472506e-109 other
1184 FCGR3A 1.957843e-113 -1.5166152 0.024 0.299 6.506695e-109 other
1185 ZC3H13 1.987613e-113 -1.9344866 0.006 0.264 6.605634e-109 other
1186 R3HDM2 2.031856e-113 -1.0730261 0.010 0.271 6.752669e-109 other
1187 PRKAR2A 2.329345e-113 -0.9623419 0.009 0.269 7.741345e-109 other
1188 CSGALNACT2 3.875897e-113 0.2571615 0.032 0.313 1.288116e-108 other
1189 ZFC3H1 3.919490e-113 -0.3450617 0.017 0.285 1.302603e-108 other
1190 INTS6 4.109840e-113 -1.1383956 0.013 0.276 1.365864e-108 other
1191 RBM22 4.910075e-113 -1.1641381 0.008 0.267 1.631814e-108 other
1192 HERC1 7.229919e-113 -0.5044909 0.016 0.283 2.402791e-108 other
1193 POLR2I 7.435957e-113 -0.2743123 0.016 0.283 2.471266e-108 other
1194 RELA 8.587312e-113 -0.6033413 0.013 0.276 2.853907e-108 other
1195 NDUFV1 8.668641e-113 0.2508537 0.026 0.301 2.880936e-108 other
1196 NUCB1 8.922785e-113 1.0369775 0.082 0.410 2.965398e-108 other
1197 MT2A 1.023183e-112 0.6803998 0.130 0.501 3.400447e-108 other
1198 CNPY2 1.664536e-112 -0.3941974 0.015 0.280 5.531919e-108 other
1199 AATF 1.813109e-112 -0.4552712 0.015 0.279 6.025687e-108 other
1200 ASXL1 1.922543e-112 -0.2652818 0.020 0.290 6.389381e-108 other
1201 GLUD1 2.009945e-112 -0.5289421 0.013 0.275 6.679851e-108 other
1202 P2RY8 2.067379e-112 -1.7610647 0.007 0.264 6.870727e-108 other
1203 RABGGTB 2.077869e-112 -1.3834713 0.008 0.266 6.905590e-108 other
1204 PMAIP1 2.384210e-112 -1.1196221 0.018 0.284 7.923685e-108 other
1205 DECR1 4.433527e-112 0.3434713 0.028 0.304 1.473438e-107 other
1206 BRI3 4.449270e-112 0.3393180 0.178 0.601 1.478671e-107 other
1207 DCXR 5.121001e-112 -0.2919461 0.014 0.277 1.701913e-107 other
1208 SHFL 6.378181e-112 0.4069945 0.032 0.312 2.119725e-107 other
1209 FOSL2 6.386757e-112 0.3874247 0.036 0.320 2.122575e-107 other
1210 SCAMP2 6.790085e-112 0.5770915 0.037 0.322 2.256617e-107 other
1211 CMTM7 6.953990e-112 -0.4475053 0.013 0.275 2.311089e-107 other
1212 KARS1 8.638380e-112 -0.3680044 0.015 0.277 2.870879e-107 other
1213 RNF13 8.644765e-112 0.3365602 0.029 0.306 2.873001e-107 other
1214 CCAR1 9.714683e-112 -0.8279097 0.011 0.270 3.228578e-107 other
1215 FGFBP2 9.798654e-112 -2.3317995 0.025 0.295 3.256485e-107 other
1216 SZRD1 1.055085e-111 0.2905935 0.030 0.308 3.506471e-107 other
1217 SETD2 1.287633e-111 -0.7568551 0.013 0.274 4.279320e-107 other
1218 ARRDC2 1.357916e-111 -1.5148630 0.007 0.262 4.512899e-107 other
1219 APPL1 1.839298e-111 -0.3383163 0.016 0.281 6.112721e-107 other
1220 PBXIP1 1.885461e-111 -2.3897908 0.005 0.258 6.266142e-107 other
1221 DAP3 2.494601e-111 -0.3023966 0.016 0.279 8.290558e-107 other
1222 ZNF428 2.739037e-111 -0.3779370 0.018 0.284 9.102917e-107 other
1223 SH3BP2 2.779999e-111 0.6955913 0.053 0.351 9.239049e-107 other
1224 SYTL3 3.695315e-111 -1.9472423 0.009 0.265 1.228101e-106 other
1225 CAVIN2 4.053207e-111 2.7792242 0.331 0.157 1.347043e-106 other
1226 RNF145 4.436571e-111 0.2582288 0.028 0.302 1.474450e-106 other
1227 TRAC 4.643657e-111 -1.2179367 0.022 0.291 1.543273e-106 other
1228 SRSF6 6.370186e-111 0.7342111 0.051 0.347 2.117068e-106 other
1229 PRKCH 6.436876e-111 -2.2653258 0.007 0.261 2.139231e-106 other
1230 CCND3 6.467910e-111 1.1801824 0.181 0.606 2.149545e-106 other
1231 HDGF 7.721058e-111 0.8111988 0.065 0.373 2.566016e-106 other
1232 STARD7 7.910698e-111 -0.3376939 0.014 0.275 2.629041e-106 other
1233 VSIR 8.607478e-111 0.7175907 0.149 0.541 2.860609e-106 other
1234 PPDPF 8.837368e-111 1.1155860 0.252 0.763 2.937011e-106 other
1235 CBX6 9.180647e-111 -0.8382027 0.013 0.272 3.051096e-106 other
1236 GIMAP1 9.221234e-111 -0.7659938 0.013 0.273 3.064585e-106 other
1237 UBE2Q1 1.102370e-110 0.7114298 0.046 0.336 3.663617e-106 other
1238 PSMD11 1.197837e-110 0.2779740 0.028 0.302 3.980893e-106 other
1239 SHOC2 1.217394e-110 0.3485248 0.032 0.310 4.045888e-106 other
1240 CD3G 1.257644e-110 -1.7925147 0.015 0.276 4.179654e-106 other
1241 NLRP1 1.258206e-110 -0.5089754 0.015 0.277 4.181522e-106 other
1242 TMEM50A 1.451648e-110 1.3129447 0.190 0.627 4.824406e-106 other
1243 MRPL10 1.462485e-110 -1.3198838 0.009 0.264 4.860423e-106 other
1244 RASSF1 2.001495e-110 -0.4101809 0.020 0.286 6.651767e-106 other
1245 ATXN10 2.187821e-110 -1.2597237 0.007 0.260 7.271006e-106 other
1246 DNAJC1 2.484612e-110 -0.3603225 0.018 0.281 8.257360e-106 other
1247 ARL2BP 2.578888e-110 -0.7669557 0.012 0.270 8.570675e-106 other
1248 CCL4 2.634448e-110 -0.8415911 0.045 0.330 8.755325e-106 other
1249 CCDC124 3.131497e-110 -0.2894015 0.014 0.274 1.040722e-105 other
1250 ABHD14B 3.673137e-110 -0.6316054 0.015 0.274 1.220730e-105 other
1251 RBBP6 3.813025e-110 1.1997840 0.112 0.464 1.267221e-105 other
1252 ABI1 4.452244e-110 0.4577819 0.035 0.314 1.479659e-105 other
1253 RAMAC 5.285685e-110 -0.3341824 0.016 0.278 1.756645e-105 other
1254 PRKX 5.719626e-110 -0.6338658 0.014 0.273 1.900860e-105 other
1255 STING1 6.233934e-110 -0.8895184 0.011 0.268 2.071786e-105 other
1256 MAP2K3 6.475627e-110 0.8761957 0.086 0.413 2.152110e-105 other
1257 MED30 9.335111e-110 -1.2565263 0.008 0.261 3.102431e-105 other
1258 MTMR14 9.722489e-110 0.2548982 0.025 0.295 3.231172e-105 other
1259 DGCR6L 1.142760e-109 -0.6473871 0.011 0.268 3.797849e-105 other
1260 MAN1A2 1.214378e-109 -0.7974674 0.012 0.268 4.035865e-105 other
1261 POLR2A 1.346643e-109 -0.4011690 0.016 0.277 4.475432e-105 other
1262 TMC8 1.431957e-109 -0.3431691 0.018 0.279 4.758966e-105 other
1263 CUL5 1.486705e-109 -1.0656257 0.010 0.264 4.940916e-105 other
1264 RRP7A 1.613286e-109 -0.3681483 0.015 0.275 5.361595e-105 other
1265 SKIL 2.347984e-109 -0.8471906 0.011 0.267 7.803290e-105 other
1266 CD2BP2 4.123875e-109 -0.4615618 0.015 0.272 1.370529e-104 other
1267 PAN3 4.216541e-109 -0.5325641 0.013 0.270 1.401325e-104 other
1268 ZBTB20 4.338621e-109 -0.6748576 0.014 0.271 1.441897e-104 other
1269 AKAP8L 4.747798e-109 -0.6168965 0.011 0.266 1.577883e-104 other
1270 SUMF2 5.863077e-109 -0.3917183 0.016 0.275 1.948535e-104 other
1271 POLR2G 6.668433e-109 0.9107087 0.060 0.361 2.216187e-104 other
1272 PSMD2 7.768375e-109 0.6096117 0.042 0.326 2.581742e-104 other
1273 POLR2E 8.180188e-109 0.9393990 0.065 0.370 2.718604e-104 other
1274 ACIN1 9.095142e-109 -0.5987651 0.014 0.271 3.022679e-104 other
1275 ATP6AP1 1.048140e-108 0.6592630 0.043 0.327 3.483388e-104 other
1276 ZNF791 1.057306e-108 -1.1819322 0.009 0.261 3.513851e-104 other
1277 DUT 1.282093e-108 0.4318151 0.033 0.308 4.260909e-104 other
1278 CTCF 1.472393e-108 -0.3112565 0.019 0.280 4.893352e-104 other
1279 SENP6 1.788984e-108 -0.3789537 0.018 0.277 5.945509e-104 other
1280 XAF1 1.946548e-108 0.3823810 0.042 0.326 6.469159e-104 other
1281 ACBD3 1.993867e-108 -0.3273585 0.016 0.275 6.626417e-104 other
1282 CDC42EP3 2.113020e-108 0.5550478 0.050 0.340 7.022412e-104 other
1283 FAM200B 2.467003e-108 -0.3694434 0.016 0.275 8.198837e-104 other
1284 NUMB 2.595638e-108 0.2846039 0.030 0.302 8.626344e-104 other
1285 RAB11B 4.078738e-108 0.5440956 0.036 0.312 1.355528e-103 other
1286 CGGBP1 4.185387e-108 0.5481291 0.041 0.322 1.390971e-103 other
1287 LGALS3 5.131762e-108 0.2866889 0.101 0.440 1.705490e-103 other
1288 ARIH2 5.158652e-108 -0.7207432 0.011 0.265 1.714426e-103 other
1289 STAT4 5.197561e-108 -1.6466099 0.008 0.257 1.727357e-103 other
1290 TSR3 5.505155e-108 -0.6376982 0.011 0.265 1.829583e-103 other
1291 RP11-160E2.6 5.857505e-108 -1.6872977 0.008 0.258 1.946683e-103 other
1292 PDXK 6.180367e-108 0.2944066 0.027 0.295 2.053983e-103 other
1293 TMEM219 8.282588e-108 1.2767287 0.140 0.515 2.752635e-103 other
1294 ARPP19 8.898530e-108 0.2754337 0.031 0.302 2.957338e-103 other
1295 STK24 2.460029e-107 0.8364630 0.051 0.339 8.175659e-103 other
1296 GON4L 2.610801e-107 -0.4599601 0.016 0.272 8.676736e-103 other
1297 IST1 3.045604e-107 0.3852178 0.030 0.300 1.012176e-102 other
1298 GBP4 3.304138e-107 -0.7514682 0.014 0.268 1.098097e-102 other
1299 SMU1 3.321938e-107 -1.0304638 0.009 0.258 1.104013e-102 other
1300 RNF130 3.326059e-107 0.3338753 0.067 0.370 1.105382e-102 other
1301 OCIAD2 4.847835e-107 -1.6479088 0.007 0.254 1.611129e-102 other
1302 AP2S1 6.361129e-107 0.9948262 0.160 0.555 2.114058e-102 other
1303 CNTRL 7.479408e-107 -1.4035942 0.008 0.255 2.485706e-102 other
1304 SFT2D1 8.504998e-107 0.5104780 0.035 0.308 2.826551e-102 other
1305 PHF1 1.264789e-106 -1.3442729 0.010 0.258 4.203398e-102 other
1306 COX20 1.474799e-106 -0.8528144 0.011 0.262 4.901348e-102 other
1307 MRPL28 1.527944e-106 0.3339590 0.025 0.289 5.077969e-102 other
1308 TXNL1 1.782953e-106 0.8889085 0.051 0.338 5.925467e-102 other
1309 PARL 1.979723e-106 -0.9514988 0.009 0.257 6.579413e-102 other
1310 MAP2K7 2.171245e-106 -0.5447965 0.015 0.268 7.215916e-102 other
1311 ZYX 2.894820e-106 0.7862562 0.088 0.409 9.620644e-102 other
1312 CACYBP 3.163451e-106 0.6930959 0.035 0.306 1.051341e-101 other
1313 SYPL1 3.402636e-106 -0.2942947 0.015 0.267 1.130832e-101 other
1314 TRAPPC6A 3.630594e-106 -1.1971778 0.009 0.256 1.206592e-101 other
1315 PHB 4.538254e-106 0.6087830 0.028 0.293 1.508243e-101 other
1316 NCBP2 4.613474e-106 -0.5626479 0.013 0.265 1.533242e-101 other
1317 ITGAE 4.779966e-106 -0.5231815 0.013 0.264 1.588574e-101 other
1318 ARAP2 4.822343e-106 -0.9806179 0.011 0.260 1.602658e-101 other
1319 SF3B4 5.972153e-106 -0.4639181 0.013 0.265 1.984785e-101 other
1320 LYRM2 7.107617e-106 -0.3871707 0.015 0.267 2.362145e-101 other
1321 SCNM1 8.665824e-106 -0.3877789 0.015 0.266 2.880000e-101 other
1322 KDM6B 9.046797e-106 0.5585585 0.044 0.324 3.006612e-101 other
1323 CCDC88B 1.314271e-105 0.4450405 0.029 0.294 4.367849e-101 other
1324 TTC39C 1.346366e-105 -1.0350964 0.010 0.256 4.474511e-101 other
1325 TCP1 1.554896e-105 0.3238805 0.029 0.294 5.167542e-101 other
1326 PNKD 1.581585e-105 0.4559661 0.032 0.300 5.256240e-101 other
1327 TCOF1 1.814408e-105 -1.2624622 0.010 0.256 6.030003e-101 other
1328 RAC1 1.832370e-105 0.7491288 0.237 0.722 6.089698e-101 other
1329 CMPK1 2.062516e-105 1.1439996 0.107 0.444 6.854565e-101 other
1330 C1orf122 2.537316e-105 -0.2981130 0.016 0.268 8.432517e-101 other
1331 RIOK3 3.195488e-105 1.1182179 0.122 0.474 1.061988e-100 other
1332 CPNE3 3.289077e-105 -0.4226429 0.013 0.262 1.093092e-100 other
1333 VTI1B 4.660268e-105 0.6470355 0.044 0.322 1.548794e-100 other
1334 GZMB 4.778136e-105 -1.4955105 0.041 0.313 1.587966e-100 other
1335 UBN1 5.186675e-105 0.4629849 0.033 0.301 1.723740e-100 other
1336 JPX 5.292771e-105 -1.1101693 0.010 0.257 1.759000e-100 other
1337 CRYBG1 6.115680e-105 -0.8456982 0.012 0.260 2.032485e-100 other
1338 RPAIN 6.400655e-105 -0.6392807 0.012 0.260 2.127194e-100 other
1339 ATXN1 7.159063e-105 -0.3883314 0.015 0.265 2.379243e-100 other
1340 ANKRD13A 7.484416e-105 -0.3255340 0.015 0.266 2.487371e-100 other
1341 STAT6 8.115090e-105 0.4498016 0.030 0.295 2.696969e-100 other
1342 MRPL21 1.032653e-104 -0.2930639 0.014 0.263 3.431918e-100 other
1343 MBTPS1 1.202657e-104 -0.3624474 0.015 0.266 3.996909e-100 other
1344 RHEB 1.474888e-104 0.8983691 0.058 0.349 4.901642e-100 other
1345 SQOR 1.678460e-104 0.5701021 0.037 0.307 5.578195e-100 other
1346 DEDD2 2.542551e-104 -0.5265423 0.012 0.259 8.449915e-100 other
1347 APLP2 3.148564e-104 0.4690660 0.133 0.496 1.046394e-99 other
1348 SF3A2 3.763861e-104 -0.6107618 0.015 0.264 1.250881e-99 other
1349 FKBP1A 3.851206e-104 0.9696736 0.177 0.585 1.279910e-99 other
1350 FAM118A 5.026680e-104 -0.6012123 0.012 0.259 1.670567e-99 other
1351 EIF4G1 6.299977e-104 -0.2913544 0.016 0.267 2.093734e-99 other
1352 CHD9 7.406124e-104 0.5545795 0.036 0.304 2.461351e-99 other
1353 PEPD 8.837918e-104 0.3129123 0.023 0.280 2.937194e-99 other
1354 DENR 9.666792e-104 -0.5247454 0.013 0.259 3.212662e-99 other
1355 IL4R 1.050641e-103 -0.7974272 0.012 0.258 3.491700e-99 other
1356 UBE2K 1.078533e-103 0.3446488 0.031 0.295 3.584396e-99 other
1357 MARCKSL1 1.099251e-103 -0.7505397 0.014 0.262 3.653250e-99 other
1358 LGALS9 1.222368e-103 0.5016413 0.041 0.313 4.062417e-99 other
1359 AP3B1 1.340288e-103 -0.4235803 0.013 0.260 4.454313e-99 other
1360 SECISBP2 1.388818e-103 0.5159940 0.039 0.311 4.615597e-99 other
1361 DYNC1LI1 1.430892e-103 -0.3740641 0.016 0.265 4.755426e-99 other
1362 KPNA6 1.566669e-103 -0.7521067 0.011 0.255 5.206667e-99 other
1363 MED13 1.624160e-103 -0.5121564 0.014 0.261 5.397732e-99 other
1364 CCDC107 1.786937e-103 -0.2759703 0.017 0.267 5.938708e-99 other
1365 NASP 1.995118e-103 0.3395728 0.027 0.285 6.630576e-99 other
1366 SAMSN1 2.267307e-103 1.2765555 0.088 0.405 7.535168e-99 other
1367 IFI27L2 2.696124e-103 1.1812871 0.089 0.407 8.960298e-99 other
1368 NAP1L4 2.792094e-103 0.6991494 0.055 0.339 9.279246e-99 other
1369 SRA1 3.316223e-103 0.6166500 0.032 0.296 1.102113e-98 other
1370 VPS26A 5.441453e-103 -0.3697053 0.018 0.267 1.808412e-98 other
1371 ECHS1 5.891613e-103 -0.2534368 0.014 0.260 1.958019e-98 other
1372 HOOK3 7.327122e-103 0.3449361 0.032 0.295 2.435096e-98 other
1373 TET2 7.971390e-103 -0.4183320 0.017 0.266 2.649212e-98 other
1374 CHMP2B 9.414491e-103 0.5147716 0.029 0.289 3.128812e-98 other
1375 C9orf16 1.039924e-102 1.3741659 0.193 0.616 3.456083e-98 other
1376 TEX264 1.096576e-102 -0.2770250 0.015 0.261 3.644360e-98 other
1377 SDF2L1 1.433593e-102 0.6353897 0.040 0.309 4.764403e-98 other
1378 ERGIC1 1.739790e-102 0.7176228 0.037 0.304 5.782019e-98 other
1379 PTK2B 1.930245e-102 0.8675524 0.042 0.315 6.414976e-98 other
1380 RARA 1.934818e-102 -0.2818586 0.016 0.264 6.430176e-98 other
1381 N4BP2L1 2.013244e-102 0.2510022 0.030 0.291 6.690815e-98 other
1382 CHD8 2.073724e-102 -0.4821956 0.012 0.256 6.891814e-98 other
1383 GAK 2.202429e-102 0.3771506 0.025 0.280 7.319552e-98 other
1384 DCP2 2.270573e-102 0.5863874 0.036 0.301 7.546023e-98 other
1385 CDK2AP2 2.589305e-102 -0.2991105 0.020 0.271 8.605295e-98 other
1386 CLDND1 2.700964e-102 -0.4548550 0.017 0.265 8.976384e-98 other
1387 ACADVL 3.534834e-102 0.8088797 0.046 0.320 1.174767e-97 other
1388 SUZ12 4.187637e-102 -0.3478365 0.016 0.262 1.391719e-97 other
1389 STX11 4.338579e-102 0.3603354 0.044 0.316 1.441883e-97 other
1390 PTGER2 5.014402e-102 -0.2578461 0.018 0.266 1.666486e-97 other
1391 TGFBR2 6.151734e-102 -0.5485658 0.015 0.259 2.044467e-97 other
1392 DNAJC2 6.195775e-102 -0.3102281 0.014 0.258 2.059104e-97 other
1393 CDC123 6.766983e-102 -0.8359200 0.011 0.252 2.248939e-97 other
1394 ARFGAP3 9.875282e-102 -0.3549222 0.015 0.260 3.281951e-97 other
1395 CHST12 1.058342e-101 -0.7578166 0.019 0.268 3.517294e-97 other
1396 PHYKPL 1.443894e-101 -0.5874585 0.011 0.253 4.798638e-97 other
1397 GALNT1 1.646737e-101 -0.7389027 0.011 0.252 5.472766e-97 other
1398 ZBTB43 1.959468e-101 0.6531022 0.039 0.305 6.512095e-97 other
1399 NINJ1 2.412679e-101 0.8365000 0.082 0.390 8.018296e-97 other
1400 SND1 2.810701e-101 -0.4021073 0.013 0.255 9.341085e-97 other
1401 ITPA 3.767160e-101 -0.5783807 0.011 0.252 1.251978e-96 other
1402 TENT2 5.522375e-101 -0.8365565 0.011 0.252 1.835306e-96 other
1403 PSME4 6.120596e-101 -0.3161847 0.020 0.267 2.034119e-96 other
1404 ZNF652 6.315872e-101 -0.5010044 0.013 0.255 2.099017e-96 other
1405 CUX1 7.519532e-101 0.5911510 0.039 0.305 2.499041e-96 other
1406 ZNF276 7.786799e-101 -0.6668887 0.012 0.253 2.587865e-96 other
1407 GNLY 7.885054e-101 -1.8832021 0.084 0.356 2.620519e-96 other
1408 SBNO1 8.705298e-101 -0.3966815 0.015 0.259 2.893119e-96 other
1409 POLR2C 8.969102e-101 -0.3052054 0.014 0.256 2.980791e-96 other
1410 ZFX 1.023684e-100 -0.6258332 0.011 0.251 3.402112e-96 other
1411 PLIN2 1.682279e-100 0.4336018 0.032 0.291 5.590886e-96 other
1412 FAM50A 1.712977e-100 0.3935910 0.029 0.284 5.692909e-96 other
1413 CSTA 4.513556e-100 -0.2647947 0.055 0.333 1.500035e-95 other
1414 DEF6 4.725253e-100 -0.2737176 0.016 0.259 1.570391e-95 other
1415 SPAG9 6.498464e-100 0.8076785 0.039 0.303 2.159699e-95 other
1416 LY86 8.340602e-100 0.2634415 0.032 0.290 2.771916e-95 other
1417 TADA3 8.482514e-100 0.4322378 0.035 0.295 2.819079e-95 other
1418 NDUFA6 1.096639e-99 1.3782743 0.119 0.455 3.644571e-95 other
1419 IFT20 1.170871e-99 -0.3618070 0.014 0.254 3.891274e-95 other
1420 CHST11 1.461825e-99 -0.3409888 0.014 0.254 4.858229e-95 other
1421 SMS 1.586424e-99 0.4168840 0.032 0.290 5.272321e-95 other
1422 LMBRD1 2.391583e-99 -0.3396502 0.016 0.257 7.948187e-95 other
1423 CAPZA2 3.530283e-99 1.2647019 0.134 0.485 1.173254e-94 other
1424 GYG1 3.921775e-99 0.5798484 0.028 0.280 1.303363e-94 other
1425 KIAA0930 4.291827e-99 -0.4578712 0.017 0.259 1.426346e-94 other
1426 PPP4R2 4.459543e-99 0.3663401 0.027 0.278 1.482085e-94 other
1427 EHD1 5.309128e-99 0.6570761 0.047 0.316 1.764436e-94 other
1428 SLK 6.541966e-99 -0.3822941 0.014 0.253 2.174157e-94 other
1429 UBL3 7.922577e-99 -0.3064644 0.014 0.253 2.632989e-94 other
1430 KIDINS220 8.526217e-99 -0.3334823 0.016 0.256 2.833603e-94 other
1431 VPS36 1.041526e-98 -0.5409720 0.013 0.250 3.461409e-94 other
1432 SRM 1.049047e-98 0.7265141 0.029 0.282 3.486403e-94 other
1433 UBE2S 1.106619e-98 0.4121484 0.029 0.281 3.677738e-94 other
1434 NAA50 1.128036e-98 0.2769266 0.023 0.271 3.748915e-94 other
1435 DNM1L 1.178744e-98 -0.4216454 0.015 0.253 3.917439e-94 other
1436 RELB 1.326643e-98 0.3212586 0.025 0.274 4.408964e-94 other
1437 ARHGAP26 1.455172e-98 -0.2994855 0.017 0.258 4.836118e-94 other
1438 SH3BP5 1.488883e-98 0.4096541 0.036 0.295 4.948155e-94 other
1439 CPVL 1.549002e-98 -0.5538688 0.034 0.291 5.147953e-94 other
1440 PIP4K2A 1.940352e-98 1.0144838 0.088 0.394 6.448565e-94 other
1441 SEMA4D 2.667546e-98 0.3696011 0.031 0.285 8.865321e-94 other
1442 DDB1 4.169413e-98 -0.3390283 0.015 0.252 1.385663e-93 other
1443 STK38 4.651776e-98 -0.4660171 0.015 0.252 1.545971e-93 other
1444 TNFSF10 4.787369e-98 0.2756514 0.034 0.290 1.591034e-93 other
1445 FLNA 5.669215e-98 0.8640690 0.248 0.729 1.884107e-93 other
1446 PPP4R3B 5.844641e-98 -0.2546569 0.017 0.257 1.942408e-93 other
1447 RNF10 7.154182e-98 0.5481775 0.040 0.301 2.377621e-93 other
1448 LSM12 1.675422e-97 0.3907723 0.026 0.273 5.568096e-93 other
1449 RAF1 1.677865e-97 1.0228875 0.044 0.309 5.576216e-93 other
1450 WAPL 1.834420e-97 -0.2868047 0.015 0.252 6.096513e-93 other
1451 RASAL3 1.900588e-97 -0.5285733 0.015 0.251 6.316413e-93 other
1452 RP11-1143G9.4 5.421427e-97 -0.8927709 0.074 0.356 1.801757e-92 other
1453 UBR4 9.258650e-97 0.4782184 0.032 0.283 3.077020e-92 other
1454 PHF20L1 1.278280e-96 0.8162983 0.048 0.313 4.248235e-92 other
1455 EMC3 1.430668e-96 1.2381675 0.106 0.425 4.754681e-92 other
1456 MIR23AHG 2.630484e-96 -0.4623827 0.019 0.258 8.742151e-92 other
1457 PSMB8-AS1 2.955689e-96 -0.2587978 0.018 0.255 9.822937e-92 other
1458 STAU1 3.299556e-96 0.3988595 0.030 0.278 1.096575e-91 other
1459 ZAP70 6.919001e-96 -0.4844368 0.020 0.258 2.299461e-91 other
1460 CHMP3 6.983628e-96 0.4411679 0.030 0.279 2.320939e-91 other
1461 CREM 1.346807e-95 -1.1496642 0.016 0.250 4.475978e-91 other
1462 MRPL55 1.428584e-95 0.3363873 0.022 0.261 4.747757e-91 other
1463 NECAP1 2.014662e-95 0.3840642 0.024 0.265 6.695527e-91 other
1464 EMP3 2.158195e-95 0.4522608 0.292 0.831 7.172546e-91 other
1465 MTPN 2.407849e-95 1.2884619 0.204 0.626 8.002246e-91 other
1466 PRDX6 2.518601e-95 1.4096497 0.179 0.572 8.370318e-91 other
1467 NLRC5 3.476678e-95 0.3521672 0.027 0.270 1.155439e-90 other
1468 PFKL 3.616281e-95 0.3702971 0.026 0.269 1.201835e-90 other
1469 CAPG 6.317292e-95 0.7027146 0.060 0.333 2.099489e-90 other
1470 ADAM8 1.164097e-94 0.4602349 0.027 0.269 3.868760e-90 other
1471 WARS1 1.440388e-94 0.3397626 0.052 0.317 4.786985e-90 other
1472 BLVRA 1.468829e-94 0.6707637 0.036 0.286 4.881507e-90 other
1473 SLBP 2.481609e-94 0.2882083 0.028 0.271 8.247379e-90 other
1474 SLC25A39 3.031220e-94 -0.6385362 0.018 0.252 1.007396e-89 other
1475 FAM91A1 3.466082e-94 0.2542240 0.022 0.259 1.151918e-89 other
1476 HSPD1 5.371192e-94 1.3180509 0.041 0.296 1.785062e-89 other
1477 BABAM1 5.869516e-94 0.4025345 0.026 0.266 1.950675e-89 other
1478 JARID2 6.621508e-94 0.9602399 0.058 0.329 2.200592e-89 other
1479 C7orf50 6.699804e-94 0.6050336 0.041 0.294 2.226613e-89 other
1480 CARHSP1 1.518851e-93 0.2792675 0.023 0.261 5.047750e-89 other
1481 IL17RA 1.518964e-93 0.4724652 0.042 0.296 5.048124e-89 other
1482 USP47 1.567744e-93 0.3064795 0.024 0.262 5.210239e-89 other
1483 NAA38 2.095247e-93 1.4073638 0.122 0.450 6.963345e-89 other
1484 FLOT1 2.878863e-93 0.6970489 0.035 0.282 9.567612e-89 other
1485 RASSF2 1.433047e-92 0.3928240 0.031 0.274 4.762588e-88 other
1486 COPS3 2.639436e-92 0.4892494 0.027 0.265 8.771902e-88 other
1487 YWHAE 2.934520e-92 1.3692269 0.114 0.433 9.752585e-88 other
1488 NMI 3.339031e-92 0.7944937 0.038 0.286 1.109694e-87 other
1489 RABGAP1L 3.375019e-92 0.6853085 0.053 0.315 1.121654e-87 other
1490 HMGB1 6.225490e-92 0.6580470 0.325 0.907 2.068979e-87 other
1491 S100A4 6.650917e-92 -0.3930830 0.434 0.841 2.210366e-87 other
1492 NRDC 6.775073e-92 0.6944127 0.044 0.298 2.251628e-87 other
1493 PAG1 7.043950e-92 0.9761581 0.042 0.294 2.340986e-87 other
1494 WASHC1 7.112768e-92 0.3565432 0.025 0.261 2.363857e-87 other
1495 AGFG1 8.085057e-92 0.8249495 0.041 0.292 2.686988e-87 other
1496 PLK3 1.886380e-91 1.0375589 0.044 0.297 6.269195e-87 other
1497 MRPS6 2.356950e-91 0.4142797 0.024 0.258 7.833089e-87 other
1498 OAZ2 2.495312e-91 0.5158586 0.029 0.267 8.292921e-87 other
1499 DCTN2 3.162211e-91 0.7973252 0.043 0.294 1.050929e-86 other
1500 FTL 3.871919e-91 0.8746855 0.869 0.988 1.286794e-86 other
1501 CLPTM1L 4.560257e-91 0.2959844 0.022 0.253 1.515556e-86 other
1502 RNPEP 6.520560e-91 0.3619669 0.025 0.259 2.167043e-86 other
1503 PPP6R1 6.721747e-91 0.6098553 0.041 0.288 2.233905e-86 other
1504 GRPEL1 1.008681e-90 0.3044624 0.021 0.251 3.352249e-86 other
1505 MED15 1.102247e-90 0.2798917 0.023 0.254 3.663208e-86 other
1506 ARPC5 2.179666e-90 1.0046753 0.211 0.630 7.243901e-86 other
1507 DUSP6 2.514565e-90 -0.4057005 0.049 0.303 8.356907e-86 other
1508 ETV6 2.767689e-90 0.4760358 0.028 0.263 9.198137e-86 other
1509 ZDHHC20 3.155319e-90 0.4062813 0.027 0.262 1.048639e-85 other
1510 CDKN2D 4.120702e-90 1.1375848 0.211 0.624 1.369474e-85 other
1511 CYB5R4 4.561744e-90 0.3743296 0.025 0.257 1.516050e-85 other
1512 DGKD 5.343583e-90 0.3786551 0.036 0.277 1.775886e-85 other
1513 ATG2A 7.871104e-90 0.6847821 0.040 0.285 2.615883e-85 other
1514 SERINC3 7.889552e-90 0.8634530 0.042 0.290 2.622014e-85 other
1515 IGF2R 7.928673e-90 0.3480233 0.027 0.261 2.635015e-85 other
1516 RGS2 9.347255e-90 0.7690207 0.084 0.369 3.106467e-85 other
1517 H2AC6 9.898441e-90 2.7406036 0.334 0.180 3.289648e-85 other
1518 NCF2 1.492291e-89 0.4047138 0.062 0.327 4.959479e-85 other
1519 DNAJC4 2.391691e-89 0.5762558 0.033 0.271 7.948545e-85 other
1520 LACTB 5.471365e-89 0.4462449 0.028 0.261 1.818353e-84 other
1521 S100A6 6.048476e-89 -0.3216474 0.415 0.866 2.010150e-84 other
1522 IFI35 9.152172e-89 0.5694248 0.030 0.265 3.041633e-84 other
1523 GPI 1.225207e-88 0.6177279 0.030 0.264 4.071853e-84 other
1524 DDIT3 1.395714e-88 0.4928647 0.030 0.264 4.638517e-84 other
1525 UBQLN1 1.416176e-88 0.4712626 0.023 0.251 4.706518e-84 other
1526 PLIN3 2.582223e-88 0.5821038 0.033 0.269 8.581760e-84 other
1527 TMOD3 2.771191e-88 0.9900310 0.053 0.308 9.209775e-84 other
1528 DENND3 2.801794e-88 1.0284938 0.045 0.292 9.311482e-84 other
1529 LSM1 3.162890e-88 0.9155791 0.052 0.305 1.051155e-83 other
1530 SKAP2 3.210842e-88 0.8528526 0.062 0.325 1.067091e-83 other
1531 GNA13 3.604209e-88 0.5847395 0.029 0.261 1.197823e-83 other
1532 UBE2F 4.128220e-88 0.9141372 0.060 0.320 1.371973e-83 other
1533 CTSB 6.182907e-88 0.7837045 0.108 0.412 2.054827e-83 other
1534 RILPL2 8.151078e-88 1.3213812 0.108 0.412 2.708929e-83 other
1535 ATP6V1E1 9.465137e-88 0.9786675 0.049 0.298 3.145643e-83 other
1536 SIAH2 1.693637e-87 0.6584546 0.047 0.294 5.628632e-83 other
1537 GAS7 2.028964e-87 0.5114722 0.036 0.273 6.743058e-83 other
1538 G6PD 2.934016e-87 0.6667654 0.039 0.278 9.750910e-83 other
1539 JMJD6 3.864037e-87 0.4396293 0.029 0.260 1.284174e-82 other
1540 LST1 8.041516e-87 -0.4225939 0.124 0.428 2.672517e-82 other
1541 PCNX1 1.690363e-86 0.6906638 0.025 0.250 5.617751e-82 other
1542 MLXIP 1.775415e-86 0.5157182 0.027 0.255 5.900415e-82 other
1543 DUSP22 4.082144e-86 0.3777069 0.028 0.255 1.356660e-81 other
1544 SLC66A2 1.350697e-85 0.9575686 0.042 0.282 4.488905e-81 other
1545 CFP 1.959271e-85 0.3806792 0.059 0.313 6.511441e-81 other
1546 ATP6V1B2 1.979911e-85 0.6686598 0.033 0.263 6.580037e-81 other
1547 TIMP2 2.657841e-85 0.6428794 0.049 0.293 8.833069e-81 other
1548 MTRNR2L12 5.532724e-85 1.1831379 0.248 0.697 1.838746e-80 other
1549 HACD4 8.958361e-85 1.0416828 0.074 0.339 2.977222e-80 other
1550 UPF3A 6.062837e-84 0.7008754 0.039 0.272 2.014923e-79 other
1551 LILRB3 7.345448e-84 0.3789159 0.037 0.268 2.441186e-79 other
1552 WDR1 8.520196e-84 1.3541951 0.155 0.495 2.831602e-79 other
1553 ARF4 2.820184e-83 0.9793534 0.048 0.288 9.372600e-79 other
1554 CMC2 4.008161e-83 0.6963096 0.039 0.270 1.332072e-78 other
1555 PCMT1 2.644468e-82 1.3288176 0.075 0.336 8.788626e-78 other
1556 DYNLL2 5.359621e-82 0.5569622 0.032 0.254 1.781217e-77 other
1557 C19orf38 9.144059e-82 0.5367664 0.033 0.256 3.038936e-77 other
1558 TOMM5 1.341413e-81 0.7800166 0.034 0.258 4.458053e-77 other
1559 LMO2 1.406972e-81 0.4112779 0.036 0.262 4.675932e-77 other
1560 RHOC 1.485438e-81 0.5338890 0.068 0.321 4.936706e-77 other
1561 PLSCR1 2.473113e-81 1.1214835 0.057 0.301 8.219144e-77 other
1562 ARAP1 2.851110e-81 0.6463925 0.030 0.250 9.475378e-77 other
1563 CPPED1 4.158166e-81 0.7625632 0.042 0.273 1.381925e-76 other
1564 PECAM1 4.987643e-81 0.7428598 0.065 0.316 1.657593e-76 other
1565 RAB1B 1.942958e-80 1.1020025 0.051 0.288 6.457227e-76 other
1566 TNFSF13B 2.341071e-80 0.5301372 0.067 0.317 7.780315e-76 other
1567 BLVRB 2.843981e-80 0.9349003 0.082 0.346 9.451686e-76 other
1568 MT-ND6 1.473407e-79 0.5415942 0.032 0.250 4.896720e-75 mt
1569 ORAI2 2.757803e-79 0.6232389 0.044 0.273 9.165281e-75 other
1570 IGSF6 5.667603e-79 0.5170791 0.042 0.268 1.883571e-74 other
1571 RBX1 6.243725e-79 1.6763037 0.188 0.553 2.075040e-74 other
1572 CNIH4 9.776793e-79 1.0119919 0.037 0.257 3.249219e-74 other
1573 MARCKS 1.808200e-78 0.4326316 0.085 0.346 6.009373e-74 other
1574 CLEC7A 2.364259e-78 0.5216337 0.055 0.291 7.857377e-74 other
1575 PTPRJ 2.861761e-78 0.9226780 0.044 0.270 9.510775e-74 other
1576 LILRB2 7.452635e-78 0.5320869 0.052 0.284 2.476809e-73 other
1577 CMIP 9.922059e-78 1.2631495 0.084 0.345 3.297497e-73 other
1578 AKIRIN2 2.385208e-77 1.3950529 0.107 0.385 7.927000e-73 other
1579 IRF7 2.811779e-77 0.8072088 0.037 0.254 9.344665e-73 other
1580 C12orf75 3.654640e-77 0.6083836 0.093 0.359 1.214583e-72 other
1581 RAB31 8.452398e-77 0.8136630 0.069 0.314 2.809070e-72 other
1582 NORAD 1.525636e-76 1.4833465 0.090 0.353 5.070300e-72 other
1583 ITGAX 4.018186e-76 0.9367194 0.044 0.266 1.335404e-71 other
1584 CYTOR 6.443717e-76 1.1083871 0.081 0.335 2.141505e-71 other
1585 HPCAL1 1.239900e-75 0.8665292 0.039 0.255 4.120683e-71 other
1586 MTRNR2L8 2.090112e-75 1.3235843 0.096 0.361 6.946278e-71 other
1587 GNAQ 3.320900e-75 0.8301267 0.042 0.261 1.103668e-70 other
1588 SPI1 5.018920e-75 0.3290768 0.114 0.394 1.667988e-70 other
1589 YIPF3 9.206373e-75 1.0601071 0.045 0.264 3.059646e-70 other
1590 PRDX3 4.656214e-74 1.0593692 0.039 0.252 1.547446e-69 other
1591 NDUFS4 4.765831e-74 1.1364272 0.041 0.256 1.583876e-69 other
1592 PGD 6.747238e-74 0.9009163 0.070 0.309 2.242377e-69 other
1593 LILRA5 1.351287e-73 0.5230352 0.052 0.275 4.490867e-69 other
1594 TUBB4B 1.711876e-73 1.3009317 0.108 0.381 5.689247e-69 other
1595 S100A11 3.244244e-73 0.2706339 0.245 0.627 1.078192e-68 other
1596 CTSD 1.427253e-72 0.8734557 0.240 0.646 4.743333e-68 other
1597 FKBP5 2.514071e-72 1.2180422 0.066 0.299 8.355264e-68 other
1598 TBXAS1 3.994048e-72 0.8888474 0.044 0.258 1.327382e-67 other
1599 NUTF2 4.238875e-72 1.2205350 0.063 0.292 1.408748e-67 other
1600 SEC14L1 4.643069e-72 1.2851148 0.079 0.322 1.543078e-67 other
1601 PLEK 1.351589e-71 1.0681590 0.194 0.548 4.491871e-67 other
1602 GRN 1.683023e-71 0.4539327 0.126 0.410 5.593359e-67 other
1603 ASAP1 1.878919e-71 0.8898111 0.046 0.258 6.244399e-67 other
1604 PPBP 2.462363e-71 2.3786067 0.394 0.266 8.183417e-67 other
1605 ISG15 4.453712e-71 1.5322162 0.134 0.424 1.480147e-66 other
1606 ISCA1 4.926472e-71 1.3088342 0.083 0.327 1.637264e-66 other
1607 IFRD1 6.763218e-71 1.0830681 0.055 0.274 2.247688e-66 other
1608 PTPN12 2.081243e-70 1.0865150 0.072 0.306 6.916802e-66 other
1609 SERPINB1 3.614162e-70 1.1771298 0.219 0.599 1.201131e-65 other
1610 RASGRP2 9.296915e-70 1.7935661 0.146 0.446 3.089737e-65 other
1611 PHC2 1.010699e-69 1.4580069 0.059 0.280 3.358955e-65 other
1612 UBE2E3 3.709143e-69 1.4103162 0.080 0.318 1.232696e-64 other
1613 CAMTA1 5.036454e-69 1.4061603 0.079 0.315 1.673815e-64 other
1614 ARF3 5.607618e-69 1.2883025 0.056 0.273 1.863636e-64 other
1615 MNDA 2.032979e-68 0.2647659 0.108 0.365 6.756403e-64 other
1616 EPSTI1 2.602547e-68 1.0176109 0.051 0.262 8.649306e-64 other
1617 KCTD20 2.645459e-68 1.0219110 0.045 0.251 8.791918e-64 other
1618 SNRPN 2.882467e-68 1.2616800 0.081 0.317 9.579590e-64 other
1619 JAK3 3.382137e-68 1.1332531 0.045 0.250 1.124019e-63 other
1620 MT-CO2 6.502081e-68 -0.2942874 0.901 0.993 2.160902e-63 mt
1621 ABTB1 1.035500e-67 1.2339017 0.055 0.268 3.441382e-63 other
1622 STX7 1.077773e-67 0.9653368 0.046 0.250 3.581871e-63 other
1623 LEPROT 2.249897e-67 1.2925024 0.084 0.321 7.477308e-63 other
1624 RIPOR2 8.826875e-67 1.7746512 0.229 0.608 2.933524e-62 other
1625 UBE2H 1.018423e-66 1.1228385 0.062 0.278 3.384627e-62 other
1626 NPTN 2.124169e-66 1.1290179 0.048 0.252 7.059463e-62 other
1627 BCL2A1 2.165422e-66 1.1243835 0.067 0.286 7.196565e-62 other
1628 CLU 1.622751e-65 2.7482475 0.331 0.208 5.393051e-61 other
1629 MT1X 2.161141e-65 1.4157716 0.052 0.257 7.182338e-61 other
1630 NCF1 2.395239e-65 0.8575229 0.161 0.460 7.960336e-61 other
1631 CCPG1 4.324769e-65 1.2177099 0.055 0.261 1.437294e-60 other
1632 RAB10 4.907325e-65 1.2288364 0.058 0.268 1.630900e-60 other
1633 TPST2 7.316967e-65 1.1898932 0.100 0.345 2.431721e-60 other
1634 PPIF 1.002922e-64 1.0314694 0.055 0.260 3.333112e-60 other
1635 LGALS1 1.154861e-63 0.4551654 0.283 0.692 3.838065e-59 other
1636 GCA 1.509710e-63 0.9856165 0.067 0.281 5.017370e-59 other
1637 ADI1 3.763370e-63 1.1441183 0.052 0.252 1.250718e-58 other
1638 GLUL 4.890468e-63 1.4888701 0.122 0.382 1.625298e-58 other
1639 IRAK3 2.180885e-62 1.4561941 0.055 0.255 7.247953e-58 other
1640 H3-3A 2.287775e-62 1.3808090 0.685 0.969 7.603193e-58 other
1641 PLEKHO1 2.541197e-62 1.4288218 0.152 0.437 8.445413e-58 other
1642 PPM1A 3.105482e-62 1.1931189 0.055 0.256 1.032076e-57 other
1643 CD63 4.280331e-62 1.0607519 0.261 0.672 1.422525e-57 other
1644 PDCD10 1.075753e-61 1.4688392 0.085 0.309 3.575157e-57 other
1645 CEBPD 1.757465e-61 0.6536635 0.146 0.422 5.840758e-57 other
1646 RAP1B 2.878045e-61 1.4292961 0.318 0.800 9.564895e-57 other
1647 MT-ATP8 8.442761e-61 1.3757808 0.064 0.269 2.805867e-56 mt
1648 OAZ1 4.433532e-60 1.6522049 0.657 0.929 1.473440e-55 other
1649 CLIC1 9.130536e-60 0.7697138 0.314 0.793 3.034442e-55 other
1650 CAPN1 1.842145e-59 1.6110988 0.109 0.349 6.122184e-55 other
1651 STXBP2 4.195407e-59 1.1658769 0.174 0.476 1.394302e-54 other
1652 NENF 6.354160e-59 1.4504631 0.068 0.271 2.111742e-54 other
1653 RTN3 1.143347e-57 1.4997223 0.109 0.345 3.799799e-53 other
1654 HK1 1.999984e-57 1.4539593 0.065 0.262 6.646746e-53 other
1655 PTTG1IP 2.072868e-57 1.3579243 0.067 0.267 6.888968e-53 other
1656 PTPN18 2.385380e-57 1.6573092 0.131 0.386 7.927573e-53 other
1657 R3HDM4 4.972854e-57 1.4567889 0.097 0.321 1.652678e-52 other
1658 ARHGDIB 1.252599e-56 0.4882847 0.361 0.907 4.162889e-52 other
1659 HTATIP2 8.567402e-56 1.4192968 0.062 0.253 2.847291e-51 other
1660 MAFB 6.797717e-55 0.4093064 0.098 0.315 2.259153e-50 other
1661 CYB5R3 6.948895e-55 1.3313803 0.064 0.255 2.309396e-50 other
1662 VDAC3 3.388214e-54 1.6345867 0.091 0.302 1.126039e-49 other
1663 ASAH1 2.585297e-53 1.2723178 0.204 0.519 8.591977e-49 other
1664 TYMP 1.907532e-52 0.2788413 0.209 0.507 6.339493e-48 other
1665 TMSB4X 5.624646e-52 0.9963158 0.906 0.988 1.869295e-47 other
1666 TGFB1 1.534033e-51 1.3207598 0.324 0.782 5.098206e-47 other
1667 CSF3R 1.645207e-51 1.6908398 0.101 0.315 5.467681e-47 other
1668 SLC25A37 4.891870e-50 1.5233309 0.121 0.345 1.625764e-45 other
1669 FCGR2A 5.018860e-50 1.1325103 0.082 0.276 1.667968e-45 other
1670 RAB4A 2.232584e-49 1.6078846 0.083 0.276 7.419768e-45 other
1671 RGS18 9.898500e-49 2.8405780 0.288 0.183 3.289667e-44 other
1672 WBP2 2.788787e-48 1.6433110 0.108 0.319 9.268256e-44 other
1673 SLC11A1 9.014991e-48 1.2243853 0.105 0.312 2.996042e-43 other
1674 LAMTOR1 1.855985e-47 1.5500812 0.265 0.634 6.168179e-43 other
1675 RAB11A 4.739622e-47 1.7451402 0.131 0.356 1.575166e-42 other
1676 FPR1 1.323829e-46 1.0745142 0.101 0.303 4.399612e-42 other
1677 PLAUR 3.445021e-45 1.3026942 0.089 0.276 1.144918e-40 other
1678 ADIPOR1 3.562491e-45 1.6112891 0.101 0.297 1.183958e-40 other
1679 IER3 6.665657e-44 1.2829503 0.088 0.271 2.215264e-39 other
1680 TLK1 2.052672e-43 1.6034373 0.094 0.280 6.821851e-39 other
1681 ACTB 2.163134e-43 0.7575137 0.846 0.984 7.188959e-39 other
1682 MAX 6.491782e-43 1.7884385 0.147 0.376 2.157479e-38 other
1683 CARD19 3.077983e-41 1.6843757 0.105 0.293 1.022937e-36 other
1684 PLBD1 1.394016e-39 1.1695411 0.096 0.273 4.632874e-35 other
1685 PKM 1.514215e-39 1.3347137 0.273 0.623 5.032341e-35 other
1686 NRGN 1.826323e-39 2.5752931 0.408 0.366 6.069603e-35 other
1687 ARPC1B 2.084175e-39 1.2683689 0.323 0.739 6.926547e-35 other
1688 SNN 7.549296e-38 1.7638147 0.090 0.257 2.508933e-33 other
1689 COTL1 9.560087e-37 0.2660346 0.324 0.684 3.177199e-32 other
1690 SNAP23 1.521558e-36 1.8530362 0.120 0.307 5.056747e-32 other
1691 H2AJ 2.159596e-36 1.9315301 0.171 0.402 7.177200e-32 other
1692 TUBA1C 2.326186e-36 1.6214163 0.093 0.257 7.730847e-32 other
1693 LAT 4.050621e-35 1.4239801 0.108 0.282 1.346183e-30 other
1694 NAP1L1 4.253593e-34 1.7392292 0.323 0.720 1.413639e-29 other
1695 GPX4 8.029034e-34 1.7465336 0.311 0.691 2.668369e-29 other
1696 NCK2 4.543740e-33 1.4971852 0.113 0.283 1.510067e-28 other
1697 NDUFAF3 1.413915e-32 1.9172202 0.122 0.299 4.699006e-28 other
1698 CD14 1.663083e-32 0.6499859 0.136 0.321 5.527091e-28 other
1699 NCOA4 2.564725e-32 1.8859511 0.188 0.417 8.523608e-28 other
1700 CFL1 3.098804e-32 0.3389805 0.413 0.925 1.029856e-27 other
1701 TALDO1 6.240702e-32 1.1732816 0.261 0.568 2.074035e-27 other
1702 CD68 7.644759e-31 1.0240861 0.164 0.370 2.540659e-26 other
1703 GSTO1 7.043689e-30 1.6959086 0.232 0.496 2.340900e-25 other
1704 S100A9 7.758357e-30 1.0897332 0.592 0.561 2.578412e-25 other
1705 IFI6 8.165092e-30 1.8175413 0.195 0.427 2.713587e-25 other
1706 CALM3 1.783236e-29 1.7226313 0.298 0.641 5.926408e-25 other
1707 NAMPT 2.615689e-28 1.8023412 0.211 0.447 8.692980e-24 other
1708 TLN1 8.134652e-28 1.9820040 0.292 0.619 2.703470e-23 other
1709 NEAT1 1.884133e-27 1.5501857 0.462 0.857 6.261728e-23 other
1710 DYNLL1 1.823019e-26 1.8078654 0.211 0.441 6.058622e-22 other
1711 ETFA 6.494128e-26 1.9455686 0.118 0.269 2.158259e-21 other
1712 OST4 8.741420e-22 1.8314903 0.391 0.839 2.905124e-17 other
1713 KIF2A 1.306043e-21 1.9776578 0.137 0.286 4.340503e-17 other
1714 EIF2AK1 1.443802e-21 2.0818689 0.139 0.290 4.798332e-17 other
1715 VCL 1.580608e-18 2.0357171 0.124 0.253 5.252992e-14 other
1716 GNAS 2.168980e-18 1.3187474 0.420 0.905 7.208388e-14 other
1717 FERMT3 3.497254e-18 1.9244791 0.263 0.507 1.162277e-13 other
1718 ILK 1.457409e-16 2.0180452 0.140 0.270 4.843554e-12 other
1719 SH3BGRL3 2.693636e-16 0.9090512 0.665 0.956 8.952030e-12 other
1720 STOM 1.852011e-15 1.9321893 0.161 0.302 6.154975e-11 other
1721 IFITM3 3.539701e-15 2.1295360 0.387 0.430 1.176384e-10 other
1722 S100A12 1.629684e-14 0.4552056 0.195 0.332 5.416093e-10 other
1723 GAPDH 5.884242e-14 0.9059238 0.610 0.922 1.955569e-09 other
1724 RSU1 1.776455e-12 2.1220141 0.159 0.284 5.903872e-08 other
1725 FCER1G 1.027324e-11 0.5485384 0.308 0.529 3.414210e-07 other
1726 TPM4 1.816600e-11 2.0001281 0.261 0.463 6.037289e-07 other
1727 CCL5 5.662543e-11 0.3474266 0.358 0.530 1.881890e-06 other
1728 ODC1 6.107194e-11 2.1174315 0.204 0.353 2.029665e-06 other
1729 ACTG1 3.985807e-10 0.4825224 0.486 0.907 1.324643e-05 other
1730 TUBA4A 1.018852e-09 2.0246905 0.263 0.455 3.386053e-05 other
1731 SAT1 5.260914e-09 1.3764400 0.537 0.797 1.748412e-04 other
1732 SOD2 5.995050e-05 2.0783150 0.259 0.415 1.000000e+00 other
1733 CTSA 3.559686e-04 2.1031921 0.269 0.419 1.000000e+00 other
1734 ITM2B 5.958429e-04 1.2821988 0.467 0.912 1.000000e+00 other
1735 RAB32 5.991634e-04 2.2042120 0.206 0.305 1.000000e+00 other
1736 YWHAH 6.501408e-04 2.2649492 0.214 0.317 1.000000e+00 other
1737 HLA-E 1.012737e-03 0.4726849 0.515 0.957 1.000000e+00 other
1738 MT-ND2 1.144595e-03 0.6024889 0.715 0.984 1.000000e+00 mt
1739 RGS10 2.384651e-03 2.1758523 0.331 0.534 1.000000e+00 other
1740 MARCHF2 4.238822e-03 2.2457250 0.231 0.339 1.000000e+00 other
1741 MYL12A 5.912612e-03 1.2015419 0.474 0.901 1.000000e+00 other
1742 TAGLN2 8.052164e-03 1.6131257 0.444 0.819 1.000000e+00 other
1743 MYL6 1.533273e-02 0.9711086 0.538 0.936 1.000000e+00 other
1744 NT5C3A 2.554644e-02 2.4622323 0.216 0.303 1.000000e+00 other
1745 CST3 2.616878e-02 0.6881170 0.402 0.485 1.000000e+00 other
1746 MPP1 5.808670e-02 2.1814328 0.188 0.251 1.000000e+00 other
1747 SRGN 2.305441e-01 0.6434543 0.501 0.844 1.000000e+00 other
1748 SERF2 2.782068e-01 0.8404501 0.537 0.963 1.000000e+00 other
1749 TIMP1 5.127304e-01 2.0396879 0.346 0.498 1.000000e+00 other
1750 IGKC 8.070496e-01 1.6080740 0.226 0.260 1.000000e+00 other
1751 LIMS1 8.741279e-01 2.2888305 0.287 0.389 1.000000e+00 other# Using the non-batched 'discard' vector for demonstration purposes,
# as it has more cells for stable calculation of 'lost'.
discard <- se$quality == "bad quality"
lost <- sparseMatrixStats::rowMeans2(se@assays$RNA$counts[,discard])
kept <- sparseMatrixStats::rowMeans2(se@assays$RNA$counts[,!discard])
library(edgeR)
logged <- cpm(cbind(lost, kept), log=TRUE, prior.count=2)
logFC <- logged[,1] - logged[,2]
abundance <- rowMeans(logged)
# Assuming you have a data frame with logFC and abundance
data.frame(logFC, abundance) %>%
rownames_to_column("gene") %>%
mutate(
gene_type = case_when(
str_detect(gene, pattern = "^MT-") ~ "mt",
str_detect(gene, pattern = "^RPS|^RPL") ~ "rb",
str_detect(gene, pattern = "^HB[^(P)]") ~ "hb",
TRUE ~ "other"
)
) %>%
ggplot(aes(x = abundance, y = logFC, color = gene_type)) +
geom_point() +
geom_hline(yintercept = 1, color = "red", linetype = "dashed") +
geom_hline(yintercept = -1, color = "red", linetype = "dashed") +
annotate("segment", x = 12, xend = 12, y = 1, yend = 3, color = "blue", arrow = arrow(length = unit(0.2, "cm"))) +
annotate("text", x = 13, y = 2, label = "poor quality", vjust = -1, hjust = 1, color = "blue") +
annotate("segment", x = 12, xend = 12, y = -Inf, yend = -1, color = "blue", arrow = arrow(length = unit(0.2, "cm"), ends = "first")) +
annotate("text", x = 12, y = -1.5, label = "good quality", vjust = 1, hjust = -0.1, color = "blue") +
theme_classic() +
labs(title = "Average Gene Expression vs. Log2 Fold Change", x = "Average Gene Expression", y = "Log2 Fold Change") 
Very few genes that are differentially expressed in the low quality cells which adds a layer of confidence that we’re not removing a true celltype. This shows ribosomal-high cells as good quality cells with some hemoglbin-high as low quality.
Resave Seurat object
saveRDS(se, '../data/Covid_Flu_Seurat_Object_Quality.rds')Session Info
sessionInfo()R version 4.3.2 (2023-10-31)
Platform: aarch64-apple-darwin20 (64-bit)
Running under: macOS Sonoma 14.5
Matrix products: default
BLAS: /Library/Frameworks/R.framework/Versions/4.3-arm64/Resources/lib/libRblas.0.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/4.3-arm64/Resources/lib/libRlapack.dylib; LAPACK version 3.11.0
locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
time zone: America/New_York
tzcode source: internal
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] edgeR_4.0.16 limma_3.58.1 ggridges_0.5.6 KernSmooth_2.23-22 fields_15.2 viridisLite_0.4.2 spam_2.10-0 DoubletFinder_2.0.4 colorBlindness_0.1.9 RColorBrewer_1.1-3 lubridate_1.9.3 forcats_1.0.0 stringr_1.5.1 dplyr_1.1.4 purrr_1.0.2 readr_2.1.5 tidyr_1.3.1 tibble_3.2.1 ggplot2_3.5.1 tidyverse_2.0.0 Seurat_5.0.3 SeuratObject_5.0.2 sp_2.1-4
loaded via a namespace (and not attached):
[1] rstudioapi_0.16.0 jsonlite_1.8.8 magrittr_2.0.3 spatstat.utils_3.0-4 farver_2.1.2 rmarkdown_2.27 vctrs_0.6.5 ROCR_1.0-11 spatstat.explore_3.2-7 htmltools_0.5.8.1 gridGraphics_0.5-1 sctransform_0.4.1 parallelly_1.37.1 htmlwidgets_1.6.4 ica_1.0-3 plyr_1.8.9 plotly_4.10.4 zoo_1.8-12 igraph_2.0.3 mime_0.12 lifecycle_1.0.4 pkgconfig_2.0.3 Matrix_1.6-5 R6_2.5.1 fastmap_1.2.0 MatrixGenerics_1.14.0 fitdistrplus_1.1-11 future_1.33.2 shiny_1.8.1.1 digest_0.6.35 colorspace_2.1-0 patchwork_1.2.0 tensor_1.5 RSpectra_0.16-1 irlba_2.3.5.1 labeling_0.4.3 progressr_0.14.0 fansi_1.0.6 spatstat.sparse_3.0-3 timechange_0.3.0 httr_1.4.7 polyclip_1.10-6 abind_1.4-5 compiler_4.3.2 withr_3.0.0 fastDummies_1.7.3 maps_3.4.2
[48] MASS_7.3-60.0.1 tools_4.3.2 lmtest_0.9-40 httpuv_1.6.15 future.apply_1.11.2 goftest_1.2-3 glue_1.7.0 nlme_3.1-164 promises_1.3.0 grid_4.3.2 Rtsne_0.17 cluster_2.1.6 reshape2_1.4.4 generics_0.1.3 gtable_0.3.5 spatstat.data_3.0-4 tzdb_0.4.0 data.table_1.15.4 hms_1.1.3 utf8_1.2.4 spatstat.geom_3.2-9 RcppAnnoy_0.0.22 ggrepel_0.9.5 RANN_2.6.1 pillar_1.9.0 RcppHNSW_0.6.0 later_1.3.2 splines_4.3.2 lattice_0.22-6 survival_3.6-4 deldir_2.0-4 tidyselect_1.2.1 locfit_1.5-9.9 miniUI_0.1.1.1 pbapply_1.7-2 knitr_1.45 gridExtra_2.3 scattermore_1.2 xfun_0.44 statmod_1.5.0 matrixStats_1.3.0 stringi_1.8.4 lazyeval_0.2.2 yaml_2.3.8 evaluate_0.23 codetools_0.2-20 cli_3.6.2
[95] uwot_0.1.16 xtable_1.8-4 reticulate_1.36.1 munsell_0.5.1 Rcpp_1.0.12 globals_0.16.3 spatstat.random_3.2-3 png_0.1-8 parallel_4.3.2 presto_1.0.0 dotCall64_1.1-1 sparseMatrixStats_1.14.0 listenv_0.9.1 scales_1.3.0 leiden_0.4.3.1 rlang_1.1.3 cowplot_1.1.3